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10.1101/gr.198937.115 http://scihub22266oqcxt.onion/10.1101/gr.198937.115 C4772019!4772019!26772196     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genome+Res 2016 ; 26 (3): 376-84 Nephropedia Template TP {{tp|p=26772196|t=2016. Assessment of megabase-scale somatic copy number variation using single-cell sequencing |pdf=|usr=}}{{26772196}} gab.com Text Assessment of megabase-scale somatic copy number variation using single-cell sequencing JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=26772196 #FOAvip Megabase-scale copy number variants (CNVs) can have profound phenotypic consequences. Germline CNVs of this magnitude are associated with disease and experience negative selection. However, it is unknown whether organismal function requires that every cell maintain a balanced genome. It is possible that large somatic CNVs are tolerated or even positively selected. Single-cell sequencing is a useful tool for assessing somatic genomic heterogeneity, but its performance in CNV detection has not been rigorously tested. Here, we develop an approach that allows for reliable detection of megabase-scale CNVs in single somatic cells. We discover large CNVs in 8%?9% of cells across tissues and identify two recurrent CNVs. We conclude that large CNVs can be tolerated in subpopulations of cells, and particular CNVs are relatively prevalent within and across individuals. Twit Text FOAVip Assessment of megabase-scale somatic copy number variation using single-cell sequencing ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=26772196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26772196 #FOAvip English Wikipedia <ref>{{Cite pmid|26772196}}</ref> Assessment of megabase-scale somatic copy number variation using single-cell sequencing #MMPMID26772196 Knouse KA; Wu J; Amon A Genome Res 2016[Mar]; 26 (3): 376-84 PMID26772196show ga Megabase-scale copy number variants (CNVs) can have profound phenotypic consequences. Germline CNVs of this magnitude are associated with disease and experience negative selection. However, it is unknown whether organismal function requires that every cell maintain a balanced genome. It is possible that large somatic CNVs are tolerated or even positively selected. Single-cell sequencing is a useful tool for assessing somatic genomic heterogeneity, but its performance in CNV detection has not been rigorously tested. Here, we develop an approach that allows for reliable detection of megabase-scale CNVs in single somatic cells. We discover large CNVs in 8%?9% of cells across tissues and identify two recurrent CNVs. We conclude that large CNVs can be tolerated in subpopulations of cells, and particular CNVs are relatively prevalent within and across individuals. äAssessment of megabase-scale somatic copy number variation using singl(epmc).pdf DeepDyve Pubget Overpricing