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10.3389/fonc.2016.00045

http://scihub22266oqcxt.onion/10.3389/fonc.2016.00045
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C4771739!4771739!26973813
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suck abstract from ncbi


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pmid26973813      Front+Oncol 2016 ; 6 (ä): ä
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  • Current Management Strategies in Breast Cancer by Targeting Key Altered Molecular Players #MMPMID26973813
  • Ali S; Mondal N; Choudhry H; Rasool M; Pushparaj PN; Khan MA; Mahfooz M; Sami GA; Jarullah J; Ali A; Jamal MS
  • Front Oncol 2016[]; 6 (ä): ä PMID26973813show ga
  • Breast cancer is the second largest disease affecting women worldwide. It remains the most frequently reported and leading cause of death among women in both developed and developing countries. Tamoxifen and raloxifene are commonly used selective estrogen receptor modulators for treatment of breast cancer in women with high risk, although resistance occurs by tamoxifen after 5?years of therapy and both drugs cause uterine cancer and thromboembolic events. Aromatase inhibitors (AIs) are one of the optional modes used for breast cancer treatment. The combination of AIs along with tamoxifen can also be beneficial. Various therapeutic agents from different sources are being studied, which further need to be improved for potential outcome. For this, clinical trials based on large number of patients with optimal dose and lesser side effects have to be more in practice. Despite the clinical trials going on, there is need of better molecular models, which can identify high risk population, new agents with better benefit having less side effects, and improved biomarkers for treating breast cancer.
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