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2016 ; 30
(3
): 278-89
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Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development,
Tumorigenesis, and Metastasis
#MMPMID26677753
Zuo Y
; Oh W
; Ulu A
; Frost JA
Mol Endocrinol
2016[Mar]; 30
(3
): 278-89
PMID26677753
show ga
Ras homolog (Rho) family small GTPases are critical regulators of actin
cytoskeletal organization, cell motility, proliferation, and survival.
Surprisingly, the large majority of the studies underlying our knowledge of Rho
protein function have been carried out in cultured cells, and it is only recently
that researchers have begun to assess Rho GTPase regulation and function in vivo.
The purpose of this review is to evaluate our current knowledge of Rho GTPase
function in mouse mammary gland development, tumorigenesis and metastasis.
Although our knowledge is still incomplete, these studies are already uncovering
important themes as to the physiological roles of Rho GTPase signaling in normal
mammary gland development and function. Essential contributions of Rho proteins
to breast cancer initiation, tumor progression, and metastatic dissemination have
also been identified.