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2016 ; 5
(ä): 215
Nephropedia Template TP
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English Wikipedia
Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by
suppression of HMGB1/RAGE/NF-?B pathway
#MMPMID27026909
Yu Y
; Yu Y
; Liu M
; Yu P
; Liu G
; Liu Y
; Su Y
; Jiang H
; Chen R
Springerplus
2016[]; 5
(ä): 215
PMID27026909
show ga
Inflammation plays important roles in the pathogenesis of coxsackievirus B3
(CVB3)-induced acute viral myocarditis (AVMC). Ethyl pyruvate (EP) has been shown
to be an anti-inflammatory agent. High mobility group box 1 (HMGB1)/receptor for
advanced glycation end product (RAGE)/nuclear factor (NF)-?B pathway has close
relation with inflammatory responses. Here, we investigated the effects of EP on
CVB3-induced AVMC and potential mechanisms. The mice with AVMC were treated with
EP (40 or 80 mg/kg/day) from day 5 to day 7 post-infection. EP significantly
decreased the mortality of mice with AVMC. H&E staining and immunohistochemistry
for HMGB1 demonstrated less inflammatory lesions and fewer abnormal location of
HMGB1 in the hearts of AVMC mice receiving EP. Immuoblot showed that EP
significantly inhibited the levels of HMGB1, RAGE, phospho(p)-NF-?B and p-I-?B?,
and raised I-?B? expression in the hearts of AVMC mice. Furthermore, real-time
PCR and Elisa displayed decreased levels of HMGB1, TNF-?, IL-1?, IL-17 and
increased levels of IL-10 in the hearts and serum of AVMC mice treated with EP.
Our findings suggest that EP protects against CVB3-induced AVMC that is
associated with inhibition of HMGB1/RAGE/NF-?B pathway.