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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Geburtshilfe+Frauenheilkd 2016 ; 76 (2): 164-9 Nephropedia Template TP
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PARP Inhibitors for Recurrent Ovarian Carcinoma: Current Treatment Options and Future Perspectives #MMPMID26941449
Sehouli J; Braicu EI; Chekerov R
Geburtshilfe Frauenheilkd 2016[Feb]; 76 (2): 164-9 PMID26941449show ga
More than simply a promising management option, PARP inhibitors can be regarded as a milestone in the development of personalised treatment of recurrent ovarian carcinoma. Their mechanism of action, known as ?synthetic lethality?, is dependent on functional differences of the DNA repair mechanisms of healthy cells and tumour cells; cells that repair DNA damage less efficiently are particularly sensitive to PARP inhibitors. Olaparib, licensed for use this year, is the best-studied PARP inhibitor used for treatment of high-grade serous ovarian carcinoma (HGSC). The efficacy of PARP inhibitors appears to be increased when used in combination with other treatments.