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2015 ; 3
(2
): 41-5
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gab.com Text
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English Wikipedia
Analgesic Effects and Safety of Desmopressin, Tramadol and Indomethacin in
Patients with Acute Renal Colic; A Randomized Clinical Trial
#MMPMID27162901
Shirazi M
; Salehipour M
; Afrasiabi MA
; Aminsharifi A
Bull Emerg Trauma
2015[Apr]; 3
(2
): 41-5
PMID27162901
show ga
OBJECTIVE: To compare the efficacy of desmopressin (DDAVP), tramadol and
indomethacin on pain intensity of patients with acute renal colic caused by
urolithiasis. METHODS: This prospective, randomized clinical trial was conducted
between July 2005 and July 2006 including 120 patients (70 men and 50 women, mean
age 38.2±5.8 years) referring to emergency room of Shahid Faghihi hospital with
renal colic caused by urolithiasis without any previous treatment. The patients
were randomly assigned to three groups: group A received tramadol 50mg
intramuscularly (n=40), group B received desmopressin 40 µg intranasally (n=40)
and group C received indomethacin 100mg rectally (n=40). The pain was assessed
both on admission and 30 minutes after the intervention. The pain intensity and
the side effects were compared between two study groups. RESULTS: There was no
significant difference between two study groups regarding the baseline
characteristics. The intensity of pain of presentation was almost similar in all
groups. In group A, 30 patients (75%), in group B, 15 patients (37.5%) and in
group C, 19 patients (47.5%) had complete pain relief. The pain intensity
decreased significantly after the intervention within all three groups (p<0.001).
CONCLUSION: According to the results of the current study, rectal indomethacin,
intramuscular tramadol and intranasal desmopressin are effective and safe routs
of controlling pain in acute renal colic secondary to urolithiasis. Tramadol was
the most effective agent in controlling the pain.