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10.18632/oncotarget.5340 http://scihub22266oqcxt.onion/10.18632/oncotarget.5340 C4770732!4770732 !26451612     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26451612 &cmd=llinks): Failed to open stream: HTTP request failed! 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A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |pdf=|usr=}}{{26451612 }} gab.com Text A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26451612 #FOAvip The alterations in carbohydrate metabolism that fuel tumor growth have been extensively studied. However, other metabolic pathways involved in malignant progression, demand further understanding. Here we describe a metabolic acyl-CoA synthetase/stearoyl-CoA desaturase ACSL/SCD network causing an epithelial-mesenchymal transition (EMT) program that promotes migration and invasion of colon cancer cells. The mesenchymal phenotype produced upon overexpression of these enzymes is reverted through reactivation of AMPK signaling. Furthermore, this network expression correlates with poorer clinical outcome of stage-II colon cancer patients. Finally, combined treatment with chemical inhibitors of ACSL/SCD selectively decreases cancer cell viability without reducing normal cells viability. Thus, ACSL/SCD network stimulates colon cancer progression through conferring increased energetic capacity and invasive and migratory properties to cancer cells, and might represent a new therapeutic opportunity for colon cancer treatment. Twit Text FOAVip A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26451612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26451612 #FOAvip English Wikipedia <ref>{{Cite pmid|26451612 }}</ref> A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy #MMPMID26451612 Sánchez-Martínez R ; Cruz-Gil S ; Gómez de Cedrón M ; Álvarez-Fernández M ; Vargas T ; Molina S ; García B ; Herranz J ; Moreno-Rubio J ; Reglero G ; Pérez-Moreno M ; Feliu J ; Malumbres M ; Ramírez de Molina A Oncotarget 2015[Nov]; 6 (36 ): 38719-36 PMID26451612 show ga The alterations in carbohydrate metabolism that fuel tumor growth have been extensively studied. However, other metabolic pathways involved in malignant progression, demand further understanding. Here we describe a metabolic acyl-CoA synthetase/stearoyl-CoA desaturase ACSL/SCD network causing an epithelial-mesenchymal transition (EMT) program that promotes migration and invasion of colon cancer cells. The mesenchymal phenotype produced upon overexpression of these enzymes is reverted through reactivation of AMPK signaling. Furthermore, this network expression correlates with poorer clinical outcome of stage-II colon cancer patients. Finally, combined treatment with chemical inhibitors of ACSL/SCD selectively decreases cancer cell viability without reducing normal cells viability. Thus, ACSL/SCD network stimulates colon cancer progression through conferring increased energetic capacity and invasive and migratory properties to cancer cells, and might represent a new therapeutic opportunity for colon cancer treatment. |*Epithelial-Mesenchymal Transition [MESH] |*Lipid Metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/physiology [MESH] |Cell Proliferation/physiology [MESH] |Coenzyme A Ligases/metabolism [MESH] |Colonic Neoplasms/genetics/*metabolism/*pathology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Neoplasm Invasiveness [MESH] |Signal Transduction [MESH]A link between lipid metabolism and epithelial-mesenchymal transition (epmc).pdf DeepDyve Pubget Overpricing