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suck abstract from ncbi


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pmid26498359      Oncotarget 2015 ; 6 (36): 38446-57
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  • Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander? #MMPMID26498359
  • Hoppstädter J; Kiemer AK
  • Oncotarget 2015[Nov]; 6 (36): 38446-57 PMID26498359show ga
  • Induction of glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids has been reported to be essential for their anti-inflammatory actions. At the same time, GILZ is actively downregulated under inflammatory conditions, resulting in an enhanced pro-inflammatory response. Two papers published in the recent past showed elevated GILZ expression in the late stage of an inflammation. Still, the manuscripts suggest seemingly contradictory roles of endogenous GILZ: one of them suggested compensatory actions by elevated corticosterone levels in GILZ knockout mice, while our own manuscript showed a distinct phenotype upon GILZ knockout in vivo. Herein, we discuss the role of GILZ in inflammation with a special focus on the influence of endogenous GILZ on macrophage responses and suggest a cell-type specific action of GILZ as an explanation for the conflicting results as presented in recent reports.
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