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10.1038/npp.2015.343 http://scihub22266oqcxt.onion/10.1038/npp.2015.343 C4770517!4770517 !26593266     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26593266 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuropsychopharmacology 2016 ; 41 (7 ): 1768-78 Nephropedia Template TP {{tp|p=26593266 |t=2016. Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans |pdf=|usr=}}{{26593266 }} gab.com Text Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans JO: Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=26593266 #FOAvip Lithium remains the gold standard in treating bipolar disorder but has unwanted toxicity and side effects. We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-like effects in animal models through lowering of inositol. Ebselen has been tested in clinical trials for other disorders, enabling us to determine for the first time the effect of a blood-brain barrier-penetrant IMPase inhibitor on human central nervous system (CNS) function. We now report that in a double-blind, placebo-controlled trial with healthy participants, acute oral ebselen reduced brain myo-inositol in the anterior cingulate cortex, consistent with CNS target engagement. Ebselen decreased slow-wave sleep and affected emotional processing by increasing recognition of some emotions, decreasing latency time in the acoustic startle paradigm, and decreasing the reinforcement of rewarding stimuli. In summary, ebselen affects the phosphoinositide cycle and has CNS effects on surrogate markers that may be relevant to the treatment of bipolar disorder that can be tested in future clinical trials. Twit Text FOAVip Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans ????Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=26593266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26593266 #FOAvip English Wikipedia <ref>{{Cite pmid|26593266 }}</ref> Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans #MMPMID26593266 Singh N ; Sharpley AL ; Emir UE ; Masaki C ; Herzallah MM ; Gluck MA ; Sharp T ; Harmer CJ ; Vasudevan SR ; Cowen PJ ; Churchill GC Neuropsychopharmacology 2016[Jun]; 41 (7 ): 1768-78 PMID26593266 show ga Lithium remains the gold standard in treating bipolar disorder but has unwanted toxicity and side effects. We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-like effects in animal models through lowering of inositol. Ebselen has been tested in clinical trials for other disorders, enabling us to determine for the first time the effect of a blood-brain barrier-penetrant IMPase inhibitor on human central nervous system (CNS) function. We now report that in a double-blind, placebo-controlled trial with healthy participants, acute oral ebselen reduced brain myo-inositol in the anterior cingulate cortex, consistent with CNS target engagement. Ebselen decreased slow-wave sleep and affected emotional processing by increasing recognition of some emotions, decreasing latency time in the acoustic startle paradigm, and decreasing the reinforcement of rewarding stimuli. In summary, ebselen affects the phosphoinositide cycle and has CNS effects on surrogate markers that may be relevant to the treatment of bipolar disorder that can be tested in future clinical trials. |Adult [MESH] |Antioxidants/*pharmacology [MESH] |Azoles/*pharmacology [MESH] |Brain/*drug effects/*metabolism [MESH] |Cross-Over Studies [MESH] |Double-Blind Method [MESH] |Emotions/drug effects [MESH] |Female [MESH] |Healthy Volunteers [MESH] |Humans [MESH] |Inositol/*metabolism [MESH] |Isoindoles [MESH] |Learning/drug effects [MESH] |Lithium/*pharmacology [MESH] |Male [MESH] |Organoselenium Compounds/*pharmacology [MESH] |Reinforcement, Psychology [MESH] |Sleep/drug effects [MESH] |Surveys and Questionnaires [MESH] |Time Factors [MESH]Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, (epmc).pdf DeepDyve Pubget Overpricing