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10.4103/1008-682X.170445 http://scihub22266oqcxt.onion/10.4103/1008-682X.170445 C4770500!4770500 !26732106     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26732106 &cmd=llinks): Failed to open stream: HTTP request failed! 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Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility |pdf=|usr=}}{{26732106 }} gab.com Text Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility JO: Asian J Androl http://www.kidney.de/pget.php?&tw=1&pmid=26732106 #FOAvip To study the major differences in the distribution of spermatozoa proteins in infertile men with varicocele by comparative proteomics and validation of their level of expression. The study-specific estimates for each varicocele outcome were combined to identify the proteins involved in varicocele-associated infertility in men irrespective of stage and laterality of their clinical varicocele. Expression levels of 5 key proteins (PKAR1A, AK7, CCT6B, HSPA2, and ODF2) involved in stress response and sperm function including molecular chaperones were validated by Western blotting. Ninety-nine proteins were differentially expressed in the varicocele group. Over 87% of the DEP involved in major energy metabolism and key sperm functions were underexpressed in the varicocele group. Key protein functions affected in the varicocele group were spermatogenesis, sperm motility, and mitochondrial dysfunction, which were further validated by Western blotting, corroborating the proteomics analysis. Varicocele is essentially a state of energy deprivation, hypoxia, and hyperthermia due to impaired blood supply, which is corroborated by down-regulation of lipid metabolism, mitochondrial electron transport chain, and Krebs cycle enzymes. To corroborate the proteomic analysis, expression of the 5 identified proteins of interest was validated by Western blotting. This study contributes toward establishing a biomarker "fingerprint" to assess sperm quality on the basis of molecular parameters. Twit Text FOAVip Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility ????Asian J Androl http://www.kidney.de/pget.php?&tw=1&pmid=26732106 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26732106 #FOAvip English Wikipedia <ref>{{Cite pmid|26732106 }}</ref> Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility #MMPMID26732106 Agarwal A ; Sharma R ; Samanta L ; Durairajanayagam D ; Sabanegh E Asian J Androl 2016[Mar]; 18 (2 ): 282-91 PMID26732106 show ga To study the major differences in the distribution of spermatozoa proteins in infertile men with varicocele by comparative proteomics and validation of their level of expression. The study-specific estimates for each varicocele outcome were combined to identify the proteins involved in varicocele-associated infertility in men irrespective of stage and laterality of their clinical varicocele. Expression levels of 5 key proteins (PKAR1A, AK7, CCT6B, HSPA2, and ODF2) involved in stress response and sperm function including molecular chaperones were validated by Western blotting. Ninety-nine proteins were differentially expressed in the varicocele group. Over 87% of the DEP involved in major energy metabolism and key sperm functions were underexpressed in the varicocele group. Key protein functions affected in the varicocele group were spermatogenesis, sperm motility, and mitochondrial dysfunction, which were further validated by Western blotting, corroborating the proteomics analysis. Varicocele is essentially a state of energy deprivation, hypoxia, and hyperthermia due to impaired blood supply, which is corroborated by down-regulation of lipid metabolism, mitochondrial electron transport chain, and Krebs cycle enzymes. To corroborate the proteomic analysis, expression of the 5 identified proteins of interest was validated by Western blotting. This study contributes toward establishing a biomarker "fingerprint" to assess sperm quality on the basis of molecular parameters. |*Proteomics [MESH] |Biomarkers/analysis [MESH] |Blotting, Western [MESH] |Case-Control Studies [MESH] |DNA Fragmentation [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Infertility, Male/*etiology/metabolism [MESH] |Male [MESH] |Mitochondrial Diseases/*etiology/metabolism [MESH] |Reactive Oxygen Species/analysis [MESH] |Sperm Motility/physiology [MESH] |Spermatogenesis/physiology [MESH] |Spermatozoa/chemistry/metabolism/physiology [MESH]Proteomic signatures of infertile men with clinical varicocele and the(epmc).pdf DeepDyve Pubget Overpricing