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10.1016/j.ejca.2015.12.016 http://scihub22266oqcxt.onion/10.1016/j.ejca.2015.12.016 C4769921!4769921!26849037     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Cancer 2016 ; 56 (ä): 131-43 Nephropedia Template TP {{tp|p=26849037|t=2016. Targeting the Tumor Microenvironment in Ovarian Cancer |pdf=|usr=}}{{26849037}} gab.com Text Targeting the Tumor Microenvironment in Ovarian Cancer JO: Eur J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26849037 #FOAvip The study of cancer initiation, growth and metastasis has traditionally been focused on cancer cells, and the view that they proliferate due to uncontrolled growth signaling owing to genetic derangements. However, uncontrolled growth in tumors cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behavior of tumors, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype.Ovarian cancer is the leading cause of death from gynecologic cancer worldwide. The majority of patients will have objective responses to standard tumor debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumor microenvironment in ovarian cancer. Herein, we review the key components of the tumor microenvironment as they pertain to this disease, outline targeting opportunities and supporting evidence thus far, and discuss resistance to therapy. Twit Text FOAVip Targeting the Tumor Microenvironment in Ovarian Cancer ????Eur J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26849037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26849037 #FOAvip English Wikipedia <ref>{{Cite pmid|26849037}}</ref> Targeting the Tumor Microenvironment in Ovarian Cancer #MMPMID26849037 Hansen JM; Coleman RL; Sood AK Eur J Cancer 2016[Mar]; 56 (ä): 131-43 PMID26849037show ga The study of cancer initiation, growth and metastasis has traditionally been focused on cancer cells, and the view that they proliferate due to uncontrolled growth signaling owing to genetic derangements. However, uncontrolled growth in tumors cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behavior of tumors, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype.Ovarian cancer is the leading cause of death from gynecologic cancer worldwide. The majority of patients will have objective responses to standard tumor debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumor microenvironment in ovarian cancer. Herein, we review the key components of the tumor microenvironment as they pertain to this disease, outline targeting opportunities and supporting evidence thus far, and discuss resistance to therapy. äTargeting the Tumor Microenvironment in Ovarian Cancer (epmc).pdf DeepDyve Pubget Overpricing