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10.1038/jhh.2014.125 http://scihub22266oqcxt.onion/10.1038/jhh.2014.125 C4769794!4769794!25631218     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hum+Hypertens 2015 ; 29 (9): 515-21 Nephropedia Template TP {{tp|p=25631218|t=2015. The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones |pdf=|usr=}}{{25631218}} gab.com Text The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones JO: J Hum Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=25631218 #FOAvip There is increasing evidence of a clinically relevant interplay between the renin-angiotensin-aldosterone system and calcium regulatory systems. Classically, the former is considered a key regulator of sodium and volume homeostasis while the latter is most often associated with skeletal health. However, emerging evidence suggests an overlap in regulatory control. Hyperaldosteronism and hyperparathyroidism represent pathophysiologic conditions that may contribute to or perpetuate each other; aldosterone regulates parathyroid hormone and associates with adverse skeletal complications, and parathyroid hormone regulates aldosterone and associates with adverse cardiovascular complications. As dysregulation in both systems is linked to poor cardiovascular and skeletal health, it is increasingly important to fully characterize how they interact in order to more precisely understand their impact on human health and potential therapies to modulate these interactions. This review describes the known clinical interactions between these two systems including observational and interventional studies. Specifically, we review studies describing the inhibition of renin activity by calcium and vitamin D, and a potentially bidirectional and stimulatory relationship between aldosterone and parathyroid hormone. Deciphering these relationships might clarify variability in outcomes research, inform the design of future intervention studies, and provide insight into the results of prior and on-going intervention studies. However, before these opportunities can be addressed, more effort must be placed on shifting observational data to the proof of concept phase. This will require reallocation of resources to conduct interventional studies and secure the necessary talent. Twit Text FOAVip The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones ????J Hum Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=25631218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25631218 #FOAvip English Wikipedia <ref>{{Cite pmid|25631218}}</ref> The Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormones #MMPMID25631218 Vaidya A; Brown JM; Williams JS J Hum Hypertens 2015[Sep]; 29 (9): 515-21 PMID25631218show ga There is increasing evidence of a clinically relevant interplay between the renin-angiotensin-aldosterone system and calcium regulatory systems. Classically, the former is considered a key regulator of sodium and volume homeostasis while the latter is most often associated with skeletal health. However, emerging evidence suggests an overlap in regulatory control. Hyperaldosteronism and hyperparathyroidism represent pathophysiologic conditions that may contribute to or perpetuate each other; aldosterone regulates parathyroid hormone and associates with adverse skeletal complications, and parathyroid hormone regulates aldosterone and associates with adverse cardiovascular complications. As dysregulation in both systems is linked to poor cardiovascular and skeletal health, it is increasingly important to fully characterize how they interact in order to more precisely understand their impact on human health and potential therapies to modulate these interactions. This review describes the known clinical interactions between these two systems including observational and interventional studies. Specifically, we review studies describing the inhibition of renin activity by calcium and vitamin D, and a potentially bidirectional and stimulatory relationship between aldosterone and parathyroid hormone. Deciphering these relationships might clarify variability in outcomes research, inform the design of future intervention studies, and provide insight into the results of prior and on-going intervention studies. However, before these opportunities can be addressed, more effort must be placed on shifting observational data to the proof of concept phase. This will require reallocation of resources to conduct interventional studies and secure the necessary talent. äThe Renin-Angiotensin-Aldosterone System and Calcium-Regulatory Hormon(epmc).pdf DeepDyve Pubget Overpricing