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2016 ; 2016
(ä): 6598307
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English Wikipedia
Motif-Based Text Mining of Microbial Metagenome Redundancy Profiling Data for
Disease Classification
#MMPMID27057545
Wang Y
; Li R
; Zhou Y
; Ling Z
; Guo X
; Xie L
; Liu L
Biomed Res Int
2016[]; 2016
(ä): 6598307
PMID27057545
show ga
BACKGROUND: Text data of 16S rRNA are informative for classifications of
microbiota-associated diseases. However, the raw text data need to be
systematically processed so that features for classification can be
defined/extracted; moreover, the high-dimension feature spaces generated by the
text data also pose an additional difficulty. RESULTS: Here we present a
Phylogenetic Tree-Based Motif Finding algorithm (PMF) to analyze 16S rRNA text
data. By integrating phylogenetic rules and other statistical indexes for
classification, we can effectively reduce the dimension of the large feature
spaces generated by the text datasets. Using the retrieved motifs in combination
with common classification methods, we can discriminate different samples of both
pneumonia and dental caries better than other existing methods. CONCLUSIONS: We
extend the phylogenetic approaches to perform supervised learning on microbiota
text data to discriminate the pathological states for pneumonia and dental
caries. The results have shown that PMF may enhance the efficiency and
reliability in analyzing high-dimension text data.