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10.1155/2016/5695641

http://scihub22266oqcxt.onion/10.1155/2016/5695641
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C4769737!4769737!26981294
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suck abstract from ncbi

pmid26981294      Case+Rep+Endocrinol 2016 ; 2016 (ä): ä
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  • Acute Kidney Injury Associated with Linagliptin #MMPMID26981294
  • Nandikanti DK; Gosmanova EO; Gosmanov AR
  • Case Rep Endocrinol 2016[]; 2016 (ä): ä PMID26981294show ga
  • Linagliptin is a dipeptidyl peptidase-IV (DPP-IV) inhibitor that is approved for the treatment of type 2 diabetes mellitus. About 5% of linagliptin is eliminated by the kidneys and no dose adjustment is recommended in kidney impairment. We report a first case of linagliptin-associated acute kidney injury (AKI) in a patient with preexisting chronic kidney disease (CKD). We hypothesize that AKI was due to renal hypoperfusion from linagliptin-induced natriuresis and intravascular volume contraction in the setting of concomitant lisinopril use, which is known to impair autoregulation and potentiate hypotension-induced AKI. It may be prudent to exert caution and closely monitor kidney function when initiating linagliptin in combination with ACE-inhibitors in CKD patients.
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