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10.1681/ASN.2015020196 http://scihub22266oqcxt.onion/10.1681/ASN.2015020196 C4769205!4769205 !26195817     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26195817 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2016 ; 27 (3 ): 863-76 Nephropedia Template TP {{tp|p=26195817 |t=2016. Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury |pdf=|usr=}}{{26195817 }} gab.com Text Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26195817 #FOAvip Endoplasmic reticulum (ER) stress is involved in the pathophysiology of kidney disease and aging, but the molecular bases underlying the biologic outcomes on the evolution of renal disease remain mostly unknown. Angiogenin (ANG) is a ribonuclease that promotes cellular adaptation under stress but its contribution to ER stress signaling remains elusive. In this study, we investigated the ANG-mediated contribution to the signaling and biologic outcomes of ER stress in kidney injury. ANG expression was significantly higher in samples from injured human kidneys than in samples from normal human kidneys, and in mouse and rat kidneys, ANG expression was specifically induced under ER stress. In human renal epithelial cells, ER stress induced ANG expression in a manner dependent on the activity of transcription factor XBP1, and ANG promoted cellular adaptation to ER stress through induction of stress granules and inhibition of translation. Moreover, the severity of renal lesions induced by ER stress was dramatically greater in ANG knockout mice (Ang(-/-)) mice than in wild-type mice. These results indicate that ANG is a critical mediator of tissue adaptation to kidney injury and reveal a physiologically relevant ER stress-mediated adaptive translational control mechanism. Twit Text FOAVip Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26195817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26195817 #FOAvip English Wikipedia <ref>{{Cite pmid|26195817 }}</ref> Angiogenin Mediates Cell-Autonomous Translational Control under Endoplasmic Reticulum Stress and Attenuates Kidney Injury #MMPMID26195817 Mami I ; Bouvier N ; El Karoui K ; Gallazzini M ; Rabant M ; Laurent-Puig P ; Li S ; Tharaux PL ; Beaune P ; Thervet E ; Chevet E ; Hu GF ; Pallet N J Am Soc Nephrol 2016[Mar]; 27 (3 ): 863-76 PMID26195817 show ga Endoplasmic reticulum (ER) stress is involved in the pathophysiology of kidney disease and aging, but the molecular bases underlying the biologic outcomes on the evolution of renal disease remain mostly unknown. Angiogenin (ANG) is a ribonuclease that promotes cellular adaptation under stress but its contribution to ER stress signaling remains elusive. In this study, we investigated the ANG-mediated contribution to the signaling and biologic outcomes of ER stress in kidney injury. ANG expression was significantly higher in samples from injured human kidneys than in samples from normal human kidneys, and in mouse and rat kidneys, ANG expression was specifically induced under ER stress. In human renal epithelial cells, ER stress induced ANG expression in a manner dependent on the activity of transcription factor XBP1, and ANG promoted cellular adaptation to ER stress through induction of stress granules and inhibition of translation. Moreover, the severity of renal lesions induced by ER stress was dramatically greater in ANG knockout mice (Ang(-/-)) mice than in wild-type mice. These results indicate that ANG is a critical mediator of tissue adaptation to kidney injury and reveal a physiologically relevant ER stress-mediated adaptive translational control mechanism. |Acute Kidney Injury/chemically induced/pathology/*physiopathology [MESH] |Adaptation, Physiological [MESH] |Animals [MESH] |Apoptosis [MESH] |Cells, Cultured [MESH] |DNA-Binding Proteins/metabolism [MESH] |Endoplasmic Reticulum Stress/*physiology [MESH] |Endoribonucleases/genetics/metabolism [MESH] |Epithelial Cells [MESH] |Gene Silencing [MESH] |Humans [MESH] |Kidney/*pathology/physiopathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Poly(ADP-ribose) Polymerases/metabolism [MESH] |Protein Biosynthesis/*physiology [MESH] |Protein Serine-Threonine Kinases/genetics/metabolism [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Regulatory Factor X Transcription Factors [MESH] |Ribonuclease, Pancreatic/genetics/*metabolism [MESH] |Signal Transduction [MESH] |Transcription Factors/metabolism [MESH] |Transcription, Genetic [MESH] |Tunicamycin [MESH]Angiogenin Mediates Cell-Autonomous Translational Control under Endopl(epmc).pdf DeepDyve Pubget Overpricing