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10.1681/ASN.2014121196 http://scihub22266oqcxt.onion/10.1681/ASN.2014121196 C4769197!4769197!26376860     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2016 ; 27 (3): 766-80 Nephropedia Template TP {{tp|p=26376860|t=2016. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments |pdf=|usr=}}{{26376860}} gab.com Text Chronic Hyponatremia Causes Neurologic and Psychologic Impairments JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26376860 #FOAvip Hyponatremia is the most common clinical electrolyte disorder. Once thought to be asymptomatic in response to adaptation by the brain, recent evidence suggests that chronic hyponatremia may be linked to attention deficits, gait disturbances, risk of falls, and cognitive impairments. Such neurologic defects are associated with a reduction in quality of life and may be a significant cause of mortality. However, because underlying diseases such as adrenal insufficiency, heart failure, liver cirrhosis, and cancer may also affect brain function, the contribution of hyponatremia alone to neurologic manifestations and the underlying mechanisms remain unclear. Using a syndrome of inappropriate secretion of antidiuretic hormone rat model, we show here that sustained reduction of serum sodium ion concentration induced gait disturbances; facilitated the extinction of a contextual fear memory; caused cognitive impairment in a novel object recognition test; and impaired long-term potentiation at hippocampal CA3?CA1 synapses. In vivo microdialysis revealed an elevated extracellular glutamate concentration in the hippocampus of chronically hyponatremic rats. A sustained low extracellular sodium ion concentration also decreased glutamate uptake by primary astrocyte cultures, suggesting an underlying mechanism of impaired long-term potentiation. Furthermore, gait and memory performances of corrected hyponatremic rats were equivalent to those of control rats. Thus, these results suggest chronic hyponatremia in humans may cause gait disturbance and cognitive impairment, but these abnormalities are reversible and careful correction of this condition may improve quality of life and reduce mortality. Twit Text FOAVip Chronic Hyponatremia Causes Neurologic and Psychologic Impairments ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26376860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26376860 #FOAvip English Wikipedia <ref>{{Cite pmid|26376860}}</ref> Chronic Hyponatremia Causes Neurologic and Psychologic Impairments #MMPMID26376860 Fujisawa H; Sugimura Y; Takagi H; Mizoguchi H; Takeuchi H; Izumida H; Nakashima K; Ochiai H; Takeuchi S; Kiyota A; Fukumoto K; Iwama S; Takagishi Y; Hayashi Y; Arima H; Komatsu Y; Murata Y; Oiso Y J Am Soc Nephrol 2016[Mar]; 27 (3): 766-80 PMID26376860show ga Hyponatremia is the most common clinical electrolyte disorder. Once thought to be asymptomatic in response to adaptation by the brain, recent evidence suggests that chronic hyponatremia may be linked to attention deficits, gait disturbances, risk of falls, and cognitive impairments. Such neurologic defects are associated with a reduction in quality of life and may be a significant cause of mortality. However, because underlying diseases such as adrenal insufficiency, heart failure, liver cirrhosis, and cancer may also affect brain function, the contribution of hyponatremia alone to neurologic manifestations and the underlying mechanisms remain unclear. Using a syndrome of inappropriate secretion of antidiuretic hormone rat model, we show here that sustained reduction of serum sodium ion concentration induced gait disturbances; facilitated the extinction of a contextual fear memory; caused cognitive impairment in a novel object recognition test; and impaired long-term potentiation at hippocampal CA3?CA1 synapses. In vivo microdialysis revealed an elevated extracellular glutamate concentration in the hippocampus of chronically hyponatremic rats. A sustained low extracellular sodium ion concentration also decreased glutamate uptake by primary astrocyte cultures, suggesting an underlying mechanism of impaired long-term potentiation. Furthermore, gait and memory performances of corrected hyponatremic rats were equivalent to those of control rats. Thus, these results suggest chronic hyponatremia in humans may cause gait disturbance and cognitive impairment, but these abnormalities are reversible and careful correction of this condition may improve quality of life and reduce mortality. äChronic Hyponatremia Causes Neurologic and Psychologic Impairments (epmc).pdf DeepDyve Pubget Overpricing