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10.1681/ASN.2014101035 http://scihub22266oqcxt.onion/10.1681/ASN.2014101035 C4769187!4769187!26293821     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2016 ; 27 (3): 835-46 Nephropedia Template TP {{tp|p=26293821|t=2016. Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli |pdf=|usr=}}{{26293821}} gab.com Text Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26293821 #FOAvip The iron-regulatory peptide hepcidin exhibits antimicrobial activity. Having previously shown hepcidin expression in the kidney, we addressed its role in urinary tract infection (UTI), which remains largely unknown. Experimental UTI was induced in wild-type (WT) and hepcidin-knockout (Hepc?/?) mice using the uropathogenic Escherichia coli CFT073 strain. Compared with infected WT mice, infected Hepc?/? mice showed a dramatic increase in renal bacterial load. Moreover, bacterial invasion was significantly dampened by the pretreatment of WT mice with hepcidin. Infected Hepc?/? mice exhibited decreased iron accumulation in the renal medulla and significant attenuation of the renal inflammatory response. Notably, we demonstrated in vitro bacteriostatic activity of hepcidin against CFT073. Furthermore, CFT073 repressed renal hepcidin, both in vivo and in cultured renal cells, and reduced phosphorylation of SMAD kinase in vivo, suggesting a bacterial strategy to escape the antimicrobial activities of hepcidin. In conclusion, we provide new mechanisms by which hepcidin contributes to renal host defense and suggest that targeting hepcidin offers a strategy to prevent bacterial invasion. Twit Text FOAVip Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26293821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26293821 #FOAvip English Wikipedia <ref>{{Cite pmid|26293821}}</ref> Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli #MMPMID26293821 Houamel D; Ducrot N; Lefebvre T; Daher R; Moulouel B; Sari MA; Letteron P; Lyoumi S; Millot S; Tourret J; Bouvet O; Vaulont S; Vandewalle A; Denamur E; Puy H; Beaumont C; Gouya L; Karim Z J Am Soc Nephrol 2016[Mar]; 27 (3): 835-46 PMID26293821show ga The iron-regulatory peptide hepcidin exhibits antimicrobial activity. Having previously shown hepcidin expression in the kidney, we addressed its role in urinary tract infection (UTI), which remains largely unknown. Experimental UTI was induced in wild-type (WT) and hepcidin-knockout (Hepc?/?) mice using the uropathogenic Escherichia coli CFT073 strain. Compared with infected WT mice, infected Hepc?/? mice showed a dramatic increase in renal bacterial load. Moreover, bacterial invasion was significantly dampened by the pretreatment of WT mice with hepcidin. Infected Hepc?/? mice exhibited decreased iron accumulation in the renal medulla and significant attenuation of the renal inflammatory response. Notably, we demonstrated in vitro bacteriostatic activity of hepcidin against CFT073. Furthermore, CFT073 repressed renal hepcidin, both in vivo and in cultured renal cells, and reduced phosphorylation of SMAD kinase in vivo, suggesting a bacterial strategy to escape the antimicrobial activities of hepcidin. In conclusion, we provide new mechanisms by which hepcidin contributes to renal host defense and suggest that targeting hepcidin offers a strategy to prevent bacterial invasion. äHepcidin as a Major Component of Renal Antibacterial Defenses against (epmc).pdf DeepDyve Pubget Overpricing