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10.1053/j.ajkd.2015.10.018

http://scihub22266oqcxt.onion/10.1053/j.ajkd.2015.10.018
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suck abstract from ncbi


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pmid26687923      Am+J+Kidney+Dis 2016 ; 67 (3): 423-30
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  • The Associations of Plant Protein Intake With All-Cause Mortality in CKD #MMPMID26687923
  • Chen X; Wei G; Jalili T; Metos J; Giri A; Cho ME; Boucher R; Greene T; Beddhu S
  • Am J Kidney Dis 2016[Mar]; 67 (3): 423-30 PMID26687923show ga
  • Background: Plant protein intake is associated with lower production of uremic toxins and lower serum phosphorus levels. Therefore, at a given total protein intake, a higher proportion of dietary protein from plant sources might be associated with lower mortality in CKD. Study Design: Observational study Settings & Participants: 14,866 NHANES III participants aged 20 years or older without missing data for plant and animal protein intake and mortality. Predictors: Plant protein?total protein ratio and total plant protein intake. Patients were stratified by eGFR < or ? 60 ml/min/1.73 m2. Outcomes: All-cause mortality. Measurements: Plant and total protein intakes were estimated from 24h dietary recalls. Mortality was ascertained by probabilistic linkage with National Death Index records through 12/31/2000. Results: The mean of plant protein intake and plant protein?total protein ratio were 24.6 ± 13.2 (SD) g/d and 33.0% ± 14.0%, respectively. The prevalence of eGFR < 60 ml/min/1.73 m2 was 4.9%. There were 2,163 deaths over an average follow-up of 8.4 years. Adjusted for demographics, smoking, alcohol use, comorbidity, BMI, calorie and total protein intake and physical inactivity, each 33% increase in plant protein?total protein ratio was not associated with mortality (HR, 0.88; 95% CI, 0.74-1.04) in the eGFR ?60 mL/min/1.73 m2 subpopulation, but was associated with lower mortality risk (HR, 0.77; 95% CI, 0.61-0.96) in the eGFR < 60 mL/min/1.73 m2 subpopulation. In sensitivity analyses, results were similar in those with eGFR < 60 mL/min/1.73 m2 defined by serum cystatin C. Limitations: Whether the results are related to plant protein itself or to other factors associated with more plant-based diets is hard to establish. Conclusions: A diet with higher proportion of protein from plant sources is associated with lower mortality in those with eGFR < 60 mL/min/1.73 m2. Future studies are warranted to determine the causal role of plant protein intake in reducing mortality in those with eGFR < 60 mL/min/1.73 m2.
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