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10.3892/mmr.2016.4781 http://scihub22266oqcxt.onion/10.3892/mmr.2016.4781 C4768993!4768993!26781977     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med+Rep 2016 ; 13 (3): 2087-93 Nephropedia Template TP {{tp|p=26781977|t=2016. Native low density lipoprotein promotes lipid raft formation in macrophages |pdf=|usr=}}{{26781977}} gab.com Text Native low density lipoprotein promotes lipid raft formation in macrophages JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26781977 #FOAvip Oxidized low-density lipoprotein (LDL) has an important role in atherogenesis; however, the mechanisms underlying cell-mediated LDL oxidation remain to be elucidated. The present study investigated whether native-LDL induced lipid raft formation, in order to gain further insight into LDL oxidation. Confocal microscopic analysis revealed that lipid rafts were aggregated or clustered in the membrane, which were colocalized with myeloperoxidase (MPO) upon native LDL stimulation; however, in the presence of methyl-?-cyclodextrin (M?CD), LDL-stimulated aggregation, translocation, and colocalization of lipid rafts components was abolished.. In addition, lipid raft disruptors M?CD and filipin decreased malondialdehyde expression levels. Density gradient centrifugation coupled to label-free quantitative proteomic analysis identified 1,449 individual proteins, of which 203 were significantly upregulated following native-LDL stimulation. Functional classification of the proteins identified in the lipid rafts revealed that the expression levels of translocation proteins were upregulated. In conclusion, the results of the present study indicated that native-LDL induced lipid raft clustering in macrophages, and the expression levels of several proteins were altered in the stimulated macrophages, which provided novel insights into the mechanism underlying LDL oxidation. Twit Text FOAVip Native low density lipoprotein promotes lipid raft formation in macrophages ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26781977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26781977 #FOAvip English Wikipedia <ref>{{Cite pmid|26781977}}</ref> Native low density lipoprotein promotes lipid raft formation in macrophages #MMPMID26781977 SONG J; PING LY; DUONG DM; GAO XY; HE CY; WEI L; WU JZ Mol Med Rep 2016[Mar]; 13 (3): 2087-93 PMID26781977show ga Oxidized low-density lipoprotein (LDL) has an important role in atherogenesis; however, the mechanisms underlying cell-mediated LDL oxidation remain to be elucidated. The present study investigated whether native-LDL induced lipid raft formation, in order to gain further insight into LDL oxidation. Confocal microscopic analysis revealed that lipid rafts were aggregated or clustered in the membrane, which were colocalized with myeloperoxidase (MPO) upon native LDL stimulation; however, in the presence of methyl-?-cyclodextrin (M?CD), LDL-stimulated aggregation, translocation, and colocalization of lipid rafts components was abolished.. In addition, lipid raft disruptors M?CD and filipin decreased malondialdehyde expression levels. Density gradient centrifugation coupled to label-free quantitative proteomic analysis identified 1,449 individual proteins, of which 203 were significantly upregulated following native-LDL stimulation. Functional classification of the proteins identified in the lipid rafts revealed that the expression levels of translocation proteins were upregulated. In conclusion, the results of the present study indicated that native-LDL induced lipid raft clustering in macrophages, and the expression levels of several proteins were altered in the stimulated macrophages, which provided novel insights into the mechanism underlying LDL oxidation. äNative low density lipoprotein promotes lipid raft formation in macrop(epmc).pdf DeepDyve Pubget Overpricing