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10.12659/MSM.897288 http://scihub22266oqcxt.onion/10.12659/MSM.897288 C4768945!4768945!26908019     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Sci+Monit 2016 ; 22 (ä): 617-24 Nephropedia Template TP {{tp|p=26908019|t=2016. MiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc |pdf=|usr=}}{{26908019}} gab.com Text MiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc JO: Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=26908019 #FOAvip Background: Epithelial ovarian cancer (EOC) is the most lethal malignant gynecological cancer. MicroRNAs (miRNAs) play important roles in the pathogenesis of ovarian cancer. The role of miR-494 in EOC has not been fully investigated. Material/methods: MiR-494 levels in ovarian cancer tissues and cells were tested by qRT-PCR. Cells were transfected with miR-494 mimics or miR-494 ASO by Lipofectamine. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-494. The c-Myc protein level was assayed by Western blot. The interaction between miR-494 and c-Myc was confirmed by dual luciferase assays. Results: MiR-494 showed low levels in EOC tissues and cells. Overexpression of miR-494 inhibited cell growth and migration of EOC cells and vice versa. c-Myc is the targeted gene of miR-494. Conclusions: MiR-494 has an anti-tumor role in EOC via c-Myc. Twit Text FOAVip MiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc ????Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=26908019 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26908019 #FOAvip English Wikipedia <ref>{{Cite pmid|26908019}}</ref> MiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc #MMPMID26908019 Yuan J; Wang K; Xi M Med Sci Monit 2016[]; 22 (ä): 617-24 PMID26908019show ga Background: Epithelial ovarian cancer (EOC) is the most lethal malignant gynecological cancer. MicroRNAs (miRNAs) play important roles in the pathogenesis of ovarian cancer. The role of miR-494 in EOC has not been fully investigated. Material/methods: MiR-494 levels in ovarian cancer tissues and cells were tested by qRT-PCR. Cells were transfected with miR-494 mimics or miR-494 ASO by Lipofectamine. Bioinformatics algorithms from TargetScanHuman were used to predict the target genes of miR-494. The c-Myc protein level was assayed by Western blot. The interaction between miR-494 and c-Myc was confirmed by dual luciferase assays. Results: MiR-494 showed low levels in EOC tissues and cells. Overexpression of miR-494 inhibited cell growth and migration of EOC cells and vice versa. c-Myc is the targeted gene of miR-494. Conclusions: MiR-494 has an anti-tumor role in EOC via c-Myc. äMiR-494 Inhibits Epithelial Ovarian Cancer Growth by Targeting c-Myc (epmc).pdf DeepDyve Pubget Overpricing