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10.1016/j.cell.2015.05.011 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.05.011 C4768733!4768733!26000480     free     free     free       Cell 2015 ; 161 (5): 999-1011 Nephropedia Template TP {{tp|p=26000480|t=2015. Treatment of Obesity with Celastrol |pdf=|usr=}}{{26000480}} gab.com Text Treatment of Obesity with Celastrol JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26000480 #FOAvip Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in silico drug screening methods we discovered that Celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilfordi (Thunder of God Vine) plant, is a powerful anti-obesity agent. Celastrol suppresses food intake, blocks reduction of energy expenditure and leads up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but is ineffective in leptin-deficient (ob/ob) or leptin receptor-deficient (db/db) mouse models. These results indicate that Celastrol is a leptin sensitizer and a promising agent for the pharmacological treatment of obesity. Twit Text FOAVip Treatment of Obesity with Celastrol ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26000480 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26000480 #FOAvip English Wikipedia <ref>{{Cite pmid|26000480}}</ref> Treatment of Obesity with Celastrol #MMPMID26000480 Liu J; Lee J; Hernandez MAS; Mazitschek R; Ozcan U Cell 2015[May]; 161 (5): 999-1011 PMID26000480show ga Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in silico drug screening methods we discovered that Celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilfordi (Thunder of God Vine) plant, is a powerful anti-obesity agent. Celastrol suppresses food intake, blocks reduction of energy expenditure and leads up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but is ineffective in leptin-deficient (ob/ob) or leptin receptor-deficient (db/db) mouse models. These results indicate that Celastrol is a leptin sensitizer and a promising agent for the pharmacological treatment of obesity. äTreatment of Obesity with Celastrol (epmc).pdf DeepDyve Pubget Overpricing