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10.1038/srep22171 http://scihub22266oqcxt.onion/10.1038/srep22171 C4768171!4768171!26916346     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26916346|t=2016. Autophagy is activated to protect against endotoxic acute kidney injury |pdf=|usr=}}{{26916346}} gab.com Text Autophagy is activated to protect against endotoxic acute kidney injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26916346 #FOAvip Endotoxemia in sepsis, characterized by systemic inflammation, is a major cause of acute kidney injury (AKI) in hospitalized patients, especially in intensive care unit; however the underlying pathogenesis is poorly understood. Autophagy is a conserved, cellular catabolic pathway that plays crucial roles in cellular homeostasis including the maintenance of cellular function and viability. The regulation and role of autophagy in septic or endotoxic AKI remains unclear. Here we show that autophagy was induced in kidney tubular cells in mice by the endotoxin lipopolysaccharide (LPS). Pharmacological inhibition of autophagy with chloroquine enhanced LPS-induced AKI. Moreover, specific ablation of autophagy gene 7 (Atg7) from kidney proximal tubules worsened LPS-induced AKI. Together, the results demonstrate convincing evidence of autophagy activation in endotoxic kidney injury and support a renoprotective role of autophagy in kidney tubules. Twit Text FOAVip Autophagy is activated to protect against endotoxic acute kidney injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26916346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26916346 #FOAvip English Wikipedia <ref>{{Cite pmid|26916346}}</ref> Autophagy is activated to protect against endotoxic acute kidney injury #MMPMID26916346 Mei S; Livingston M; Hao J; li L; Mei C; Dong Z Sci Rep 2016[]; 6 (ä): ä PMID26916346show ga Endotoxemia in sepsis, characterized by systemic inflammation, is a major cause of acute kidney injury (AKI) in hospitalized patients, especially in intensive care unit; however the underlying pathogenesis is poorly understood. Autophagy is a conserved, cellular catabolic pathway that plays crucial roles in cellular homeostasis including the maintenance of cellular function and viability. The regulation and role of autophagy in septic or endotoxic AKI remains unclear. Here we show that autophagy was induced in kidney tubular cells in mice by the endotoxin lipopolysaccharide (LPS). Pharmacological inhibition of autophagy with chloroquine enhanced LPS-induced AKI. Moreover, specific ablation of autophagy gene 7 (Atg7) from kidney proximal tubules worsened LPS-induced AKI. Together, the results demonstrate convincing evidence of autophagy activation in endotoxic kidney injury and support a renoprotective role of autophagy in kidney tubules. äAutophagy is activated to protect against endotoxic acute kidney injur(epmc).pdf DeepDyve Pubget Overpricing