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10.4331/wjbc.v7.i1.64 http://scihub22266oqcxt.onion/10.4331/wjbc.v7.i1.64 C4768125!4768125!26981196     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Biol+Chem 2016 ; 7 (1): 64-77 Nephropedia Template TP {{tp|p=26981196|t=2016. Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk |pdf=|usr=}}{{26981196}} gab.com Text Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk JO: World J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26981196 #FOAvip Cell-cell and cell-matrix signaling and communication between adhesion sites involve mechanisms which are required for cellular functions during normal development and homeostasis; however these cellular functions and mechanisms are often deregulated in cancer. Aberrant signaling at cell-cell and cell-matrix adhesion sites often involves downstream mediators including Rho GTPases and tyrosine kinases. This review discusses these molecules as putative mediators of cellular crosstalk between cell-cell and cell-matrix adhesion sites, in addition to their attractiveness as therapeutic targets in cancer. Interestingly, inter-junctional crosstalk mechanisms are frequently typified by the way in which bacterial and viral pathogens opportunistically infect or intoxicate mammalian cells. This review therefore also discusses the concept of learning from pathogen-host interaction studies to better understand coordinated communication between cell-cell and cell-matrix adhesion sites, in addition to highlighting the potential therapeutic usefulness of exploiting pathogens or their products to tap into inter-junctional crosstalk. Taken together, we feel that increased knowledge around mechanisms of cell-cell and cell-matrix adhesion site crosstalk and consequently a greater understanding of their therapeutic targeting offers a unique opportunity to contribute to the emerging molecular revolution in cancer biology. Twit Text FOAVip Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk ????World J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26981196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26981196 #FOAvip English Wikipedia <ref>{{Cite pmid|26981196}}</ref> Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk #MMPMID26981196 Smith YE; Vellanki SH; Hopkins AM World J Biol Chem 2016[Feb]; 7 (1): 64-77 PMID26981196show ga Cell-cell and cell-matrix signaling and communication between adhesion sites involve mechanisms which are required for cellular functions during normal development and homeostasis; however these cellular functions and mechanisms are often deregulated in cancer. Aberrant signaling at cell-cell and cell-matrix adhesion sites often involves downstream mediators including Rho GTPases and tyrosine kinases. This review discusses these molecules as putative mediators of cellular crosstalk between cell-cell and cell-matrix adhesion sites, in addition to their attractiveness as therapeutic targets in cancer. Interestingly, inter-junctional crosstalk mechanisms are frequently typified by the way in which bacterial and viral pathogens opportunistically infect or intoxicate mammalian cells. This review therefore also discusses the concept of learning from pathogen-host interaction studies to better understand coordinated communication between cell-cell and cell-matrix adhesion sites, in addition to highlighting the potential therapeutic usefulness of exploiting pathogens or their products to tap into inter-junctional crosstalk. Taken together, we feel that increased knowledge around mechanisms of cell-cell and cell-matrix adhesion site crosstalk and consequently a greater understanding of their therapeutic targeting offers a unique opportunity to contribute to the emerging molecular revolution in cancer biology. äDynamic interplay between adhesion surfaces in carcinomas: Cell-cell a(epmc).pdf DeepDyve Pubget Overpricing