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10.1038/oncsis.2015.25 http://scihub22266oqcxt.onion/10.1038/oncsis.2015.25 C4767937!4767937!26344693     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2015 ; 4 (9): e166- Nephropedia Template TP {{tp|p=26344693|t=2015. FOXO1 inhibits osteosarcoma oncogenesis via Wnt/?-catenin pathway suppression |pdf=|usr=}}{{26344693}} gab.com Text FOXO1 inhibits osteosarcoma oncogenesis via Wnt/ -catenin pathway suppression JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=26344693 #FOAvip Recent advances have highlighted profound roles of FOXO transcription factors, especially FOXO1, in bone development and remodeling. The regulation of bone development by FOXOs seems to be stage-specific or context dependent. FOXOs promote maintenance and differentiation of early progenitors of the osteoblast lineage and repress proliferation of committed osteoblast precursors; FOXO1 is vital for osteocyte survival. Considering the versatile roles played by FOXOs in bone development and tumorigenesis, it is plausible that FOXO1, the main FOXO in bone with a non-redundant role, might have influence on osteosarcoma (OS) oncogenesis. Indeed, recent results have implicated that FOXO1 has a tumor-suppressing role in OS. In the present study, we found that FOXO1 expression was generally low or absent in OS, with a minority of cases having moderate expression. Whole-genome sequencing (WGS) revealed that the FOXO1 locus was frequently involved in copy number variation and loss of heterozygosity in OS, indicating that chromosomal aberrations might be partially responsible for the heterogeneity in FOXO1 expression. FOXO1 activation in OS cell lines inhibited cancer cell survival, which can be attributed to modulation of target genes, including BIM and repressed Wnt/?-catenin signaling. FOXO1 inhibition promoted cell proliferation, enhanced colony formation and attenuated osteogenic differentiation of OS cell lines. To conclude, our results proved FOXO1 as a tumor suppressor in OS at least partially by suppression of the Wnt/?-catenin pathway. Twit Text FOAVip FOXO1 inhibits osteosarcoma oncogenesis via Wnt/ -catenin pathway suppression ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=26344693 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26344693 #FOAvip English Wikipedia <ref>{{Cite pmid|26344693}}</ref> FOXO1 inhibits osteosarcoma oncogenesis via Wnt/?-catenin pathway suppression #MMPMID26344693 Guan H; Tan P; Xie L; Mi B; Fang Z; Li J; Yue J; Liao H; Li F Oncogenesis 2015[Sep]; 4 (9): e166- PMID26344693show ga Recent advances have highlighted profound roles of FOXO transcription factors, especially FOXO1, in bone development and remodeling. The regulation of bone development by FOXOs seems to be stage-specific or context dependent. FOXOs promote maintenance and differentiation of early progenitors of the osteoblast lineage and repress proliferation of committed osteoblast precursors; FOXO1 is vital for osteocyte survival. Considering the versatile roles played by FOXOs in bone development and tumorigenesis, it is plausible that FOXO1, the main FOXO in bone with a non-redundant role, might have influence on osteosarcoma (OS) oncogenesis. Indeed, recent results have implicated that FOXO1 has a tumor-suppressing role in OS. In the present study, we found that FOXO1 expression was generally low or absent in OS, with a minority of cases having moderate expression. Whole-genome sequencing (WGS) revealed that the FOXO1 locus was frequently involved in copy number variation and loss of heterozygosity in OS, indicating that chromosomal aberrations might be partially responsible for the heterogeneity in FOXO1 expression. FOXO1 activation in OS cell lines inhibited cancer cell survival, which can be attributed to modulation of target genes, including BIM and repressed Wnt/?-catenin signaling. FOXO1 inhibition promoted cell proliferation, enhanced colony formation and attenuated osteogenic differentiation of OS cell lines. To conclude, our results proved FOXO1 as a tumor suppressor in OS at least partially by suppression of the Wnt/?-catenin pathway. äFOXO1 inhibits osteosarcoma oncogenesis via Wnt/?-catenin pathway supp(epmc).pdf DeepDyve Pubget Overpricing