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10.1002/art.39497 http://scihub22266oqcxt.onion/10.1002/art.39497 C4767665!4767665!26636433     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arthritis+Rheumatol 2016 ; 68 (3): 724-9 Nephropedia Template TP {{tp|p=26636433|t=2016. Primary Sjögren?s syndrome patients with autoantibodies against TRIM38 show greater severity of disease |pdf=|usr=}}{{26636433}} gab.com Text Primary Sjögren s syndrome patients with autoantibodies against TRIM38 show greater severity of disease JO: Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=26636433 #FOAvip Objectives: Autoantibodies reactive with Ro52 (tripartite motif (TRIM) containing protein 21 [TRIM21]) are detected in 70% of primary Sjögren?s syndrome (pSjS) patients. TRIM21 belongs to a 34 member C-IV family of TRIM proteins. Although autoantibodies against other TRIM proteins within the C-IV family have been detected in the sera of pSjS patients, their clinical relevance remains unclear. This study investigates the frequency of anti-TRIM38 in pSjS patients and evaluates its association with different clinical measures of the disease. Methods: Serum samples from pSjS patients (n=235) and controls (n=50) were analyzed for reactivity to in vitro transcribed and translated 35S-Met-TRIM38 protein. The association of anti-TRIM38 with different laboratory and clinical measures of pSjS were evaluated. Reactivity of anti-TRIM38 with different structural domains of TRIM38 was analyzed. Affinity purified anti-TRIM38 antibodies were used to immunoprecipitate TRIM21. Results: TRIM38 reactive autoantibodies were detected in the sera of 24/235 pSjS patients and in 2/50 controls. Anti-TRIM38 positivity was significantly associated with the presence of anti-Ro60, anti-Ro52, anti-La, rheumatoid factor and hypergammaglobulinemia. Clinically, anti-TRIM38 was associated with significantly higher ocular surface staining scores, lower Schirmer?s test scores and minor labial salivary gland biopsy focus scores of ?3.0. Anti-TRIM38 antibodies mainly recognized the Cortactin-binding protein-2 (CortBP-2, amino acids 128?238) and the B30.2/SPRY (amino acids 268?465) domains on TRIM38. Affinity purified antibodies to TRIM38-CortBP2 and TRIM38-B30.2/SPRY domains reacted with TRIM21. Conclusion: Our data demonstrate that anti-TRIM38 specificity arising in a subset of pSjS patients is associated with higher severity of pSjS. Twit Text FOAVip Primary Sjögren s syndrome patients with autoantibodies against TRIM38 show greater severity of disease ????Arthritis Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=26636433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26636433 #FOAvip English Wikipedia <ref>{{Cite pmid|26636433}}</ref> Primary Sjögren?s syndrome patients with autoantibodies against TRIM38 show greater severity of disease #MMPMID26636433 Wolska N; Rybakowska P; Rasmussen A; Brown M; Montgomery C; Klopocki A; Grundahl K; Scofield RH; Radfar L; Stone DU; Anaya JM; Ice JA; Lessard CJ; Lewis DM; Rhodus NL; Gopalakrishnan R; Huang AJW; Hughes PJ; Rohrer MD; Weismann MH; Venuturupalli S; Guthridge JM; James JA; Sivils KL; Bagavant H; Deshmukh US Arthritis Rheumatol 2016[Mar]; 68 (3): 724-9 PMID26636433show ga Objectives: Autoantibodies reactive with Ro52 (tripartite motif (TRIM) containing protein 21 [TRIM21]) are detected in 70% of primary Sjögren?s syndrome (pSjS) patients. TRIM21 belongs to a 34 member C-IV family of TRIM proteins. Although autoantibodies against other TRIM proteins within the C-IV family have been detected in the sera of pSjS patients, their clinical relevance remains unclear. This study investigates the frequency of anti-TRIM38 in pSjS patients and evaluates its association with different clinical measures of the disease. Methods: Serum samples from pSjS patients (n=235) and controls (n=50) were analyzed for reactivity to in vitro transcribed and translated 35S-Met-TRIM38 protein. The association of anti-TRIM38 with different laboratory and clinical measures of pSjS were evaluated. Reactivity of anti-TRIM38 with different structural domains of TRIM38 was analyzed. Affinity purified anti-TRIM38 antibodies were used to immunoprecipitate TRIM21. Results: TRIM38 reactive autoantibodies were detected in the sera of 24/235 pSjS patients and in 2/50 controls. Anti-TRIM38 positivity was significantly associated with the presence of anti-Ro60, anti-Ro52, anti-La, rheumatoid factor and hypergammaglobulinemia. Clinically, anti-TRIM38 was associated with significantly higher ocular surface staining scores, lower Schirmer?s test scores and minor labial salivary gland biopsy focus scores of ?3.0. Anti-TRIM38 antibodies mainly recognized the Cortactin-binding protein-2 (CortBP-2, amino acids 128?238) and the B30.2/SPRY (amino acids 268?465) domains on TRIM38. Affinity purified antibodies to TRIM38-CortBP2 and TRIM38-B30.2/SPRY domains reacted with TRIM21. Conclusion: Our data demonstrate that anti-TRIM38 specificity arising in a subset of pSjS patients is associated with higher severity of pSjS. äPrimary Sjögren?s syndrome patients with autoantibodies against TRIM38(epmc).pdf DeepDyve Pubget Overpricing