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http://scihub22266oqcxt.onion/ C4767476!4767476!26536657     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (40): 42854-67 Nephropedia Template TP {{tp|p=26536657|t=2015. HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation |pdf=|usr=}}{{26536657}} gab.com Text HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26536657 #FOAvip HRD1 (3-hydroxy-3-methylglutaryl reductase degradation) is an E3 ubiquitin ligase. We found that HRD1 was significantly downregulated in 170 breast cancer tissues. Low tumoral HRD1 expression was correlated with clinicopathological characteristics and a shorter survival in breast cancer patients. P65 specifically bound to the HRD1 promoter and inhibited HRD1 expression. Suppression of NF-?B activity reversed IL-6-induced downregulation of HRD1 expression. HRD1 interacted with IGF-1R and promoted its ubiquitination and degradation by the proteasome. Overexpression of HRD1 resulted in the inhibition of growth, migration and invasion of breast cancer cells in vitro and in vivo. Furthermore, HRD1 attenuated IL-6-induced epithelial-mesenchymal transition in MCF10A cells. These findings uncover a novel role for HRD1 in breast cancer. Twit Text FOAVip HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26536657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26536657 #FOAvip English Wikipedia <ref>{{Cite pmid|26536657}}</ref> HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation #MMPMID26536657 Xu YM; Wang HJ; Chen F; Guo WH; Wang YY; Li HY; Tang JH; Ding Y; Shen YC; Li M; Xuan WY; Liu LH; Wang J; Wang XR; Gao ZJ; Liang XB; Su DM Oncotarget 2015[Dec]; 6 (40): 42854-67 PMID26536657show ga HRD1 (3-hydroxy-3-methylglutaryl reductase degradation) is an E3 ubiquitin ligase. We found that HRD1 was significantly downregulated in 170 breast cancer tissues. Low tumoral HRD1 expression was correlated with clinicopathological characteristics and a shorter survival in breast cancer patients. P65 specifically bound to the HRD1 promoter and inhibited HRD1 expression. Suppression of NF-?B activity reversed IL-6-induced downregulation of HRD1 expression. HRD1 interacted with IGF-1R and promoted its ubiquitination and degradation by the proteasome. Overexpression of HRD1 resulted in the inhibition of growth, migration and invasion of breast cancer cells in vitro and in vivo. Furthermore, HRD1 attenuated IL-6-induced epithelial-mesenchymal transition in MCF10A cells. These findings uncover a novel role for HRD1 in breast cancer. äHRD1 suppresses the growth and metastasis of breast cancer cells by pr(epmc).pdf DeepDyve Pubget Overpricing