Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

http://scihub22266oqcxt.onion/ C4767460!4767460!26315396     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (40): 42651-60 Nephropedia Template TP {{tp|p=26315396|t=2015. EMT-induced metabolite signature identifies poor clinical outcome |pdf=|usr=}}{{26315396}} gab.com Text EMT-induced metabolite signature identifies poor clinical outcome JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26315396 #FOAvip Metabolic reprogramming is a hallmark of cancer. Epithelial-mesenchymal transition (EMT) induces cancer stem cell (CSC) characteristics and promotes tumor invasiveness; however relatively little is known about the metabolic reprogramming in EMT. Here we show that breast epithelial cells undergo metabolic reprogramming following EMT. Relative to control, cell lines expressing EMT transcription factors show ?1.5-fold accumulation of glutamine, glutamate, beta-alanine and glycylleucine as well as ?1.5-fold reduction of phosphoenolpyruvate, urate, and deoxycarnitine. Moreover, these metabolic alterations were found to be predictive of overall survival (hazard ratio = 2.3 (95% confidence interval: 1.31?4.2), logrank p-value = 0.03) and define breast cancer molecular subtypes. EMT-associated metabolites are primarily composed of anapleurotic precursors, suggesting that cells undergoing EMT have a shift in energy production. In summary, we describe a unique panel of metabolites associated with EMT and demonstrate that these metabolites have the potential for predicting clinical and biological characteristics associated with patient survival. Twit Text FOAVip EMT-induced metabolite signature identifies poor clinical outcome ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26315396 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26315396 #FOAvip English Wikipedia <ref>{{Cite pmid|26315396}}</ref> EMT-induced metabolite signature identifies poor clinical outcome #MMPMID26315396 Bhowmik SK; Ramirez-Peņa E; Arnold JM; Putluri V; Sphyris N; Michailidis G; Putluri N; Ambs S; Sreekumar A; Mani SA Oncotarget 2015[Dec]; 6 (40): 42651-60 PMID26315396show ga Metabolic reprogramming is a hallmark of cancer. Epithelial-mesenchymal transition (EMT) induces cancer stem cell (CSC) characteristics and promotes tumor invasiveness; however relatively little is known about the metabolic reprogramming in EMT. Here we show that breast epithelial cells undergo metabolic reprogramming following EMT. Relative to control, cell lines expressing EMT transcription factors show ?1.5-fold accumulation of glutamine, glutamate, beta-alanine and glycylleucine as well as ?1.5-fold reduction of phosphoenolpyruvate, urate, and deoxycarnitine. Moreover, these metabolic alterations were found to be predictive of overall survival (hazard ratio = 2.3 (95% confidence interval: 1.31?4.2), logrank p-value = 0.03) and define breast cancer molecular subtypes. EMT-associated metabolites are primarily composed of anapleurotic precursors, suggesting that cells undergoing EMT have a shift in energy production. In summary, we describe a unique panel of metabolites associated with EMT and demonstrate that these metabolites have the potential for predicting clinical and biological characteristics associated with patient survival. äEMT-induced metabolite signature identifies poor clinical outcome (epmc).pdf DeepDyve Pubget Overpricing