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http://scihub22266oqcxt.onion/ C4767456!4767456!26460959     free     free     free       Oncotarget 2015 ; 6 (40): 42603-12 Nephropedia Template TP {{tp|p=26460959|t=2015. The double face of Morgana in tumorigenesis |pdf=|usr=}}{{26460959}} gab.com Text The double face of Morgana in tumorigenesis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26460959 #FOAvip Morgana is a chaperone protein able to bind to ROCK I and II and to inhibit their kinase activity. Rho kinases are multifunctional proteins involved in different cellular processes, including cytoskeleton organization, centrosome duplication, cell survival and proliferation. In human cancer samples Morgana appears to be either downregulated or overexpressed, and experimental evidence indicate that Morgana behaves both as an oncosuppressor and as a proto-oncogene. Our most recent findings demonstrated that if on the one hand low Morgana expression levels, by inducing ROCK II hyperactivation, cause centrosome overduplication and genomic instability, on the other hand, Morgana overexpression induces tumor cell survival and chemoresistance through the ROCK I-PTEN-AKT axis. Therefore, Morgana belongs to a new class of proteins, displaying both oncogenic and oncosuppressor features, depending on the specific cellular context. Twit Text FOAVip The double face of Morgana in tumorigenesis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26460959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26460959 #FOAvip English Wikipedia <ref>{{Cite pmid|26460959}}</ref> The double face of Morgana in tumorigenesis #MMPMID26460959 Brancaccio M; Rocca S; Seclì L; Busso E; Fusella F Oncotarget 2015[Dec]; 6 (40): 42603-12 PMID26460959show ga Morgana is a chaperone protein able to bind to ROCK I and II and to inhibit their kinase activity. Rho kinases are multifunctional proteins involved in different cellular processes, including cytoskeleton organization, centrosome duplication, cell survival and proliferation. In human cancer samples Morgana appears to be either downregulated or overexpressed, and experimental evidence indicate that Morgana behaves both as an oncosuppressor and as a proto-oncogene. Our most recent findings demonstrated that if on the one hand low Morgana expression levels, by inducing ROCK II hyperactivation, cause centrosome overduplication and genomic instability, on the other hand, Morgana overexpression induces tumor cell survival and chemoresistance through the ROCK I-PTEN-AKT axis. Therefore, Morgana belongs to a new class of proteins, displaying both oncogenic and oncosuppressor features, depending on the specific cellular context. äThe double face of Morgana in tumorigenesis (epmc).pdf DeepDyve Pubget Overpricing