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10.1371/journal.pone.0149430 http://scihub22266oqcxt.onion/10.1371/journal.pone.0149430 C4767252!4767252!26914657     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (2): ä Nephropedia Template TP {{tp|p=26914657|t=2016. Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function |pdf=|usr=}}{{26914657}} gab.com Text Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26914657 #FOAvip The thymus is the site of T cell development and selection. In addition to lymphocytes, the thymus is composed of several types of stromal cells that are exquisitely organized to create the appropriate environment and microenvironment to support the development and selection of maturing T cells. Thymic epithelial cells (TECs) are one of the more important cell types in the thymic stroma, and they play a critical role in selecting functional T cell clones and supporting their development. In this study, we used a mouse genetics approach to investigate the consequences of deleting the Pten tumor suppressor gene in the TEC compartment of the developing thymus. We found that PTEN deficiency in TECs results in a smaller thymus with significantly disordered architecture and histology. Accordingly, loss of PTEN function also results in decreased T cells with a shift in the distribution of T cell subtypes towards CD8+ T cells. These experiments demonstrate that PTEN is critically required for the development of a functional thymic epithelium in mice. This work may help better understand the effects that certain medical conditions or clinical interventions have upon the thymus and immune function. Twit Text FOAVip Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26914657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26914657 #FOAvip English Wikipedia <ref>{{Cite pmid|26914657}}</ref> Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function #MMPMID26914657 Garfin PM; Nguyen T; Sage J PLoS One 2016[]; 11 (2): ä PMID26914657show ga The thymus is the site of T cell development and selection. In addition to lymphocytes, the thymus is composed of several types of stromal cells that are exquisitely organized to create the appropriate environment and microenvironment to support the development and selection of maturing T cells. Thymic epithelial cells (TECs) are one of the more important cell types in the thymic stroma, and they play a critical role in selecting functional T cell clones and supporting their development. In this study, we used a mouse genetics approach to investigate the consequences of deleting the Pten tumor suppressor gene in the TEC compartment of the developing thymus. We found that PTEN deficiency in TECs results in a smaller thymus with significantly disordered architecture and histology. Accordingly, loss of PTEN function also results in decreased T cells with a shift in the distribution of T cell subtypes towards CD8+ T cells. These experiments demonstrate that PTEN is critically required for the development of a functional thymic epithelium in mice. This work may help better understand the effects that certain medical conditions or clinical interventions have upon the thymus and immune function. äLoss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function(epmc).pdf DeepDyve Pubget Overpricing