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10.1111/bcp.12731 http://scihub22266oqcxt.onion/10.1111/bcp.12731 C4767210!4767210!26469689     free     free     free       Br+J+Clin+Pharmacol 2016 ; 81 (3): 428-36 Nephropedia Template TP {{tp|p=26469689|t=2016. Flumazenil, naloxone and the ?coma cocktail? |pdf=|usr=}}{{26469689}} gab.com Text Flumazenil, naloxone and the coma cocktail JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26469689 #FOAvip Flumazenil and naloxone are considered to be pharmacologically ideal antidotes. By competitive binding at the molecular target receptors, they are highly specific antagonists of two important drug classes, the benzodiazepines and opioids, respectively. Both antidotes enjoy rapid onset and short duration after parenteral administration, are easily titrated and are essentially devoid of agonist effects. Yet only naloxone is widely used as a component of the ?coma cocktail?, a sequence of empirical treatments to correct altered mental status, while experts discourage the use of flumazenil for such patients. This review contrasts the history, indications, published evidence and novel applications for each antidote in order to explain this disparity in the clinical use of these ?ideal? antidotes. Twit Text FOAVip Flumazenil, naloxone and the coma cocktail ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26469689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26469689 #FOAvip English Wikipedia <ref>{{Cite pmid|26469689}}</ref> Flumazenil, naloxone and the ?coma cocktail? #MMPMID26469689 Sivilotti ML Br J Clin Pharmacol 2016[Mar]; 81 (3): 428-36 PMID26469689show ga Flumazenil and naloxone are considered to be pharmacologically ideal antidotes. By competitive binding at the molecular target receptors, they are highly specific antagonists of two important drug classes, the benzodiazepines and opioids, respectively. Both antidotes enjoy rapid onset and short duration after parenteral administration, are easily titrated and are essentially devoid of agonist effects. Yet only naloxone is widely used as a component of the ?coma cocktail?, a sequence of empirical treatments to correct altered mental status, while experts discourage the use of flumazenil for such patients. This review contrasts the history, indications, published evidence and novel applications for each antidote in order to explain this disparity in the clinical use of these ?ideal? antidotes. äFlumazenil, naloxone and the ?coma cocktail? (epmc).pdf DeepDyve Pubget Overpricing