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10.1038/srep21731 http://scihub22266oqcxt.onion/10.1038/srep21731 C4766576!4766576 !26911838     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26911838 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma |pdf=|usr=}}{{26911838 }} gab.com Text Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26911838 #FOAvip Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in human melanoma, and promotes melanoma metastasis. The dietary flavonoid apigenin is a bioactive compound that possesses low toxicity and exerts anti-metastatic activity in melanoma. However, the anti-metastasis mechanism of apigenin has not been fully elucidated. In the present study, we showed that apigenin suppressed murine melanoma B16F10 cell lung metastasis in mice, and inhibited cell migration and invasion in human and murine melanoma cells. Further study indicated that apigenin effectively suppressed STAT3 phosphorylation, decreased STAT3 nuclear localization and inhibited STAT3 transcriptional activity. Apigenin also down-regulated STAT3 target genes MMP-2, MMP-9, VEGF and Twist1, which are involved in cell migration and invasion. More importantly, overexpression of STAT3 or Twist1 partially reversed apigenin-impaired cell migration and invasion. Our data not only reveal a novel anti-metastasis mechanism of apigenin but also support the notion that STAT3 is an attractive and promising target for melanoma treatment. Twit Text FOAVip Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26911838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26911838 #FOAvip English Wikipedia <ref>{{Cite pmid|26911838 }}</ref> Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma #MMPMID26911838 Cao HH ; Chu JH ; Kwan HY ; Su T ; Yu H ; Cheng CY ; Fu XQ ; Guo H ; Li T ; Tse AK ; Chou GX ; Mo HB ; Yu ZL Sci Rep 2016[Feb]; 6 (ä): 21731 PMID26911838 show ga Signal transducer and activator of transcription 3 (STAT3) signaling is constantly activated in human melanoma, and promotes melanoma metastasis. The dietary flavonoid apigenin is a bioactive compound that possesses low toxicity and exerts anti-metastatic activity in melanoma. However, the anti-metastasis mechanism of apigenin has not been fully elucidated. In the present study, we showed that apigenin suppressed murine melanoma B16F10 cell lung metastasis in mice, and inhibited cell migration and invasion in human and murine melanoma cells. Further study indicated that apigenin effectively suppressed STAT3 phosphorylation, decreased STAT3 nuclear localization and inhibited STAT3 transcriptional activity. Apigenin also down-regulated STAT3 target genes MMP-2, MMP-9, VEGF and Twist1, which are involved in cell migration and invasion. More importantly, overexpression of STAT3 or Twist1 partially reversed apigenin-impaired cell migration and invasion. Our data not only reveal a novel anti-metastasis mechanism of apigenin but also support the notion that STAT3 is an attractive and promising target for melanoma treatment. |Animals [MESH] |Apigenin/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Down-Regulation/drug effects [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Humans [MESH] |Immunoblotting [MESH] |Lung Neoplasms/pathology/secondary [MESH] |Matrix Metalloproteinase 2/metabolism [MESH] |Matrix Metalloproteinase 9/metabolism [MESH] |Melanoma/metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Microscopy, Fluorescence [MESH] |Neoplasm Invasiveness/prevention & control [MESH] |Phosphorylation/drug effects [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |STAT3 Transcription Factor/antagonists & inhibitors/genetics/*metabolism [MESH] |Signal Transduction/*drug effects [MESH] |Twist-Related Protein 1/antagonists & inhibitors/genetics/metabolism [MESH]Inhibition of the STAT3 signaling pathway contributes to apigenin-medi(epmc).pdf DeepDyve Pubget Overpricing