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Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic
peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats
#MMPMID26989296
Ozaki K
; Hamano H
; Matsuura T
; Narama I
J Toxicol Pathol
2016[Jan]; 29
(1
): 1-6
PMID26989296
show ga
The relationship between hypertension and diabetic peripheral neuropathy (DPN)
has recently been reported in clinical research, but it remains unclear whether
hypertension is a risk factor for DPN. To investigate the effects of hypertension
on DPN, we analyzed morphological features of peripheral nerves in diabetic rats
with hypertension. Male WBN/Kob rats were divided into 2 groups: alloxan-induced
diabetic rats with deoxycorticosterone acetate-salt (DOCA-salt) treatment (ADN
group) and nondiabetic rats with DOCA-salt treatment (DN group). Sciatic, tibial
(motor) and sural (sensory) nerves were subjected to qualitative and quantitative
histomorphological analysis. Systolic blood pressure in the two groups exhibited
a higher value (>140 mmHg), but there was no significant difference between the
two groups. Endoneurial blood vessels in both groups presented endothelial
hypertrophy and narrowing of the vascular lumen. Electron microscopically,
duplication of basal lamina surrounding the endothelium and pericyte of the
endoneurial vessels was observed, and this lesion appeared to be more frequent
and severe in the ADN group than the DN group. Many nerve fibers of the ADN and
DN groups showed an almost normal appearance, whereas morphometrical analysis of
the tibial nerve showed a significant shift to smaller fiber and myelin sizes in
the ADN group compared with DN group. In sural nerve, the fiber and axon-size
significantly shifted to a smaller size in ADN group compared with the DN group.
These results suggest that combined diabetes and hypertension could induce mild
peripheral nerve lesions with vascular changes.
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