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10.1038/srep21950 http://scihub22266oqcxt.onion/10.1038/srep21950 C4766505!4766505 !26911537     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26911537 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 21950 Nephropedia Template TP {{tp|p=26911537 |t=2016. Macrophage-derived Lipocalin-2 contributes to ischemic resistance mechanisms by protecting from renal injury |pdf=|usr=}}{{26911537 }} gab.com Text Macrophage-derived Lipocalin-2 contributes to ischemic resistance mechanisms by protecting from renal injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26911537 #FOAvip Renal ischemia-reperfusion injury triggers an inflammatory response associated to infiltrating macrophages which determines the further outcome of disease. Brown Norway rats are known to show endogenous resistance to ischemia-induced renal damage. By contrast, Sprague Dawley rats exhibit a higher susceptibility to ischemic injury. In order to ascertain cytoprotective mechanisms, we focused on the implication of lipocalin-2 protein in main resistance mechanisms in renal ischemia/reperfusion injury by using adoptive macrophage administration, genetically modified ex vivo either to overexpress or to knockdown lipocalin-2. In vitro experiments with bone marrow-derived macrophages both from Brown Norway rats and from Sprague Dawley rats under hypoxic conditions showed endogenous differences regarding cytokine and lipocalin-2 expression profile in the two strains. Most interestingly, we observed that macrophages of the resistant strain express significantly more lipocalin-2. In vivo studies showed that tubular epithelial cell apoptosis and renal injury significantly increased and reparative markers decreased in Brown Norway rats after injection of lipocalin-2-knockdown macrophages, while the administration of lipocalin-2-overexpressing cells significantly decreased Sprague Dawley susceptibility. These data point to a crucial role of macrophage-derived lipocalin-2 in endogenous cytoprotective mechanisms. We conclude that expression of lipocalin-2 in tissue-infiltrating macrophages is pivotal for kidney-intrinsic cytoprotective pathways during ischemia reperfusion injury. Twit Text FOAVip Macrophage-derived Lipocalin-2 contributes to ischemic resistance mechanisms by protecting from renal injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26911537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26911537 #FOAvip English Wikipedia <ref>{{Cite pmid|26911537 }}</ref> Macrophage-derived Lipocalin-2 contributes to ischemic resistance mechanisms by protecting from renal injury #MMPMID26911537 Jung M ; Brüne B ; Hotter G ; Sola A Sci Rep 2016[Feb]; 6 (ä): 21950 PMID26911537 show ga Renal ischemia-reperfusion injury triggers an inflammatory response associated to infiltrating macrophages which determines the further outcome of disease. Brown Norway rats are known to show endogenous resistance to ischemia-induced renal damage. By contrast, Sprague Dawley rats exhibit a higher susceptibility to ischemic injury. In order to ascertain cytoprotective mechanisms, we focused on the implication of lipocalin-2 protein in main resistance mechanisms in renal ischemia/reperfusion injury by using adoptive macrophage administration, genetically modified ex vivo either to overexpress or to knockdown lipocalin-2. In vitro experiments with bone marrow-derived macrophages both from Brown Norway rats and from Sprague Dawley rats under hypoxic conditions showed endogenous differences regarding cytokine and lipocalin-2 expression profile in the two strains. Most interestingly, we observed that macrophages of the resistant strain express significantly more lipocalin-2. In vivo studies showed that tubular epithelial cell apoptosis and renal injury significantly increased and reparative markers decreased in Brown Norway rats after injection of lipocalin-2-knockdown macrophages, while the administration of lipocalin-2-overexpressing cells significantly decreased Sprague Dawley susceptibility. These data point to a crucial role of macrophage-derived lipocalin-2 in endogenous cytoprotective mechanisms. We conclude that expression of lipocalin-2 in tissue-infiltrating macrophages is pivotal for kidney-intrinsic cytoprotective pathways during ischemia reperfusion injury. |Animals [MESH] |Blood Urea Nitrogen [MESH] |Bone Marrow Cells/cytology [MESH] |CD11b Antigen/metabolism [MESH] |Cells, Cultured [MESH] |Creatinine/blood [MESH] |Cytokines/genetics/metabolism [MESH] |Disease Models, Animal [MESH] |Flow Cytometry [MESH] |Ki-67 Antigen/genetics/metabolism [MESH] |Kidney/metabolism/pathology [MESH] |Lipocalin-2/antagonists & inhibitors/genetics/*metabolism [MESH] |Lipopolysaccharides/toxicity [MESH] |Macrophages/cytology/drug effects/*metabolism [MESH] |Male [MESH] |Microscopy, Fluorescence [MESH] |Proliferating Cell Nuclear Antigen/genetics/metabolism [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH] |Rats [MESH] |Rats, Inbred BN [MESH] |Rats, Sprague-Dawley [MESH] |Real-Time Polymerase Chain Reaction [MESH]Macrophage-derived Lipocalin-2 contributes to ischemic resistance mech(epmc).pdf DeepDyve Pubget Overpricing