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10.1038/srep21243 http://scihub22266oqcxt.onion/10.1038/srep21243 C4766491!4766491!26912274     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26912274|t=2016. Novel loci and pathways significantly associated with longevity |pdf=|usr=}}{{26912274}} gab.com Text Novel loci and pathways significantly associated with longevity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26912274 #FOAvip Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, including two novel loci (rs2069837-IL6; rs2440012-ANKRD20A9P) with genome-wide significance and the rest with suggestive significance (P?<?3.65?×?10?5). Eight independent SNPs overlapped across Han Chinese, European and U.S. populations, and APOE and 5q33.3 were replicated as longevity loci. Integrated analysis indicates four pathways (starch, sucrose and xenobiotic metabolism; immune response and inflammation; MAPK; calcium signaling) highly associated with longevity (P???0.006) in Han Chinese. The association with longevity of three of these four pathways (MAPK; immunity; calcium signaling) is supported by findings in other human cohorts. Our novel finding on the association of starch, sucrose and xenobiotic metabolism pathway with longevity is consistent with the previous results from Drosophilia. This study suggests protective mechanisms including immunity and nutrient metabolism and their interactions with environmental stress play key roles in human longevity. Twit Text FOAVip Novel loci and pathways significantly associated with longevity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26912274 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26912274 #FOAvip English Wikipedia <ref>{{Cite pmid|26912274}}</ref> Novel loci and pathways significantly associated with longevity #MMPMID26912274 Zeng Y; Nie C; Min J; Liu X; Li M; Chen H; Xu H; Wang M; Ni T; Li Y; Yan H; Zhang JP; Song C; Chi LQ; Wang HM; Dong J; Zheng GY; Lin L; Qian F; Qi Y; Liu X; Cao H; Wang Y; Zhang L; Li Z; Zhou Y; Wang Y; Lu J; Li J; Qi M; Bolund L; Yashin A; Land KC; Gregory S; Yang Z; Gottschalk W; Tao W; Wang J; Wang J; Xu X; Bae H; Nygaard M; Christiansen L; Christensen K; Franceschi C; Lutz MW; Gu J; Tan Q; Perls T; Sebastiani P; Deelen J; Slagboom E; Hauser E; Xu H; Tian XL; Yang H; Vaupel JW Sci Rep 2016[]; 6 (ä): ä PMID26912274show ga Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, including two novel loci (rs2069837-IL6; rs2440012-ANKRD20A9P) with genome-wide significance and the rest with suggestive significance (P? äNovel loci and pathways significantly associated with longevity (epmc).pdf DeepDyve Pubget Overpricing