Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncomms10787 http://scihub22266oqcxt.onion/10.1038/ncomms10787 C4766415!4766415 !26902880     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26902880 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26902880 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10787 Nephropedia Template TP {{tp|p=26902880 |t=2016. Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity |pdf=|usr=}}{{26902880 }} gab.com Text Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26902880 #FOAvip Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a potent TTR aggregation inhibitor. Tolcapone binds specifically to TTR in human plasma, stabilizes the native tetramer in vivo in mice and humans and inhibits TTR cytotoxicity. Crystal structures of tolcapone bound to wild-type TTR and to the V122I cardiomyopathy-associated variant show that it docks better into the TTR T4 pocket than tafamidis, so far the only drug on the market to treat TTR amyloidoses. These data indicate that tolcapone, already in clinical trials for familial amyloid polyneuropathy, is a strong candidate for therapeutic intervention in these diseases, including those affecting the central nervous system, for which no small-molecule therapy exists. Twit Text FOAVip Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26902880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26902880 #FOAvip English Wikipedia <ref>{{Cite pmid|26902880 }}</ref> Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity #MMPMID26902880 Sant'Anna R ; Gallego P ; Robinson LZ ; Pereira-Henriques A ; Ferreira N ; Pinheiro F ; Esperante S ; Pallares I ; Huertas O ; Almeida MR ; Reixach N ; Insa R ; Velazquez-Campoy A ; Reverter D ; Reig N ; Ventura S Nat Commun 2016[Feb]; 7 (ä): 10787 PMID26902880 show ga Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a potent TTR aggregation inhibitor. Tolcapone binds specifically to TTR in human plasma, stabilizes the native tetramer in vivo in mice and humans and inhibits TTR cytotoxicity. Crystal structures of tolcapone bound to wild-type TTR and to the V122I cardiomyopathy-associated variant show that it docks better into the TTR T4 pocket than tafamidis, so far the only drug on the market to treat TTR amyloidoses. These data indicate that tolcapone, already in clinical trials for familial amyloid polyneuropathy, is a strong candidate for therapeutic intervention in these diseases, including those affecting the central nervous system, for which no small-molecule therapy exists. |Administration, Oral [MESH] |Amyloid Neuropathies, Familial/*drug therapy [MESH] |Animals [MESH] |Benzophenones/pharmacology/*therapeutic use [MESH] |Catechol O-Methyltransferase Inhibitors/pharmacology/*therapeutic use [MESH] |Cell Line [MESH] |Dimerization [MESH] |Drug Repositioning [MESH] |Healthy Volunteers [MESH] |Humans [MESH] |Mice, Transgenic [MESH] |Middle Aged [MESH] |Nitrophenols/pharmacology/*therapeutic use [MESH] |Prealbumin/drug effects/*metabolism [MESH] |Protein Aggregation, Pathological/*drug therapy [MESH]Repositioning tolcapone as a potent inhibitor of transthyretin amyloid(epmc).pdf DeepDyve Pubget Overpricing