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10.1038/srep21962 http://scihub22266oqcxt.onion/10.1038/srep21962 C4766395!4766395 !26911903     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26911903 &cmd=llinks): Failed to open stream: HTTP request failed! 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Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families |pdf=|usr=}}{{26911903 }} gab.com Text Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26911903 #FOAvip Centenarians are a good healthy aging model. Interestingly, centenarians' offspring are prone to achieve longevity. Here we recruited 60 longevity families and investigated the blood biochemical indexes of family members to seek candidate factors associated with familial longevity. First, associations of blood indexes with age were tested. Second, associations of blood parameters in centenarians (CEN) with their first generation of offspring (F1) and F1 spouses (F1SP) were analyzed. Third, genes involved in regulating target factors were investigated. We found that total cholesterol (TC) and triglyceride (TG) increased with age (20-80 years), but decreased in CEN. Similarly, blood urea nitrogen (BUN) and blood creatinine (BCr) increased with age (20-80 years), but were maintained on a plateau in CEN. Importantly, we first revealed dual changes in blood pressure, i.e., decreased diastolic blood pressure but increased systolic blood pressure in CEN, which associated with altered CST3 expression. Genetic analysis revealed a significant association of blood uric acid (BUA) and BCr in CEN with F1 but not with F1SP, suggesting they may be heritable traits. Taken together, our results suggest serum lipids, kidney function and especially diastolic pressure rather than systolic pressure were improved in CEN or their offspring, suggesting these factors may play an important role in familial longevity. Twit Text FOAVip Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26911903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26911903 #FOAvip English Wikipedia <ref>{{Cite pmid|26911903 }}</ref> Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families #MMPMID26911903 He YH ; Pu SY ; Xiao FH ; Chen XQ ; Yan DJ ; Liu YW ; Lin R ; Liao XP ; Yu Q ; Yang LQ ; Yang XL ; Ge MX ; Li Y ; Jiang JJ ; Cai WW ; Kong QP Sci Rep 2016[Feb]; 6 (ä): 21962 PMID26911903 show ga Centenarians are a good healthy aging model. Interestingly, centenarians' offspring are prone to achieve longevity. Here we recruited 60 longevity families and investigated the blood biochemical indexes of family members to seek candidate factors associated with familial longevity. First, associations of blood indexes with age were tested. Second, associations of blood parameters in centenarians (CEN) with their first generation of offspring (F1) and F1 spouses (F1SP) were analyzed. Third, genes involved in regulating target factors were investigated. We found that total cholesterol (TC) and triglyceride (TG) increased with age (20-80 years), but decreased in CEN. Similarly, blood urea nitrogen (BUN) and blood creatinine (BCr) increased with age (20-80 years), but were maintained on a plateau in CEN. Importantly, we first revealed dual changes in blood pressure, i.e., decreased diastolic blood pressure but increased systolic blood pressure in CEN, which associated with altered CST3 expression. Genetic analysis revealed a significant association of blood uric acid (BUA) and BCr in CEN with F1 but not with F1SP, suggesting they may be heritable traits. Taken together, our results suggest serum lipids, kidney function and especially diastolic pressure rather than systolic pressure were improved in CEN or their offspring, suggesting these factors may play an important role in familial longevity. |*Longevity [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Aging [MESH] |Asian People [MESH] |Blood Pressure/*physiology [MESH] |Blood Urea Nitrogen [MESH] |China [MESH] |Cholesterol/blood [MESH] |Creatinine/blood [MESH] |Cystatin C/metabolism [MESH] |Humans [MESH] |Kidney Function Tests [MESH] |Kidney/*metabolism [MESH] |Lipid Metabolism/genetics [MESH] |Lipids/*blood [MESH] |Male [MESH] |Middle Aged [MESH] |Transcriptome [MESH] |Triglycerides/blood [MESH]Improved lipids, diastolic pressure and kidney function are potential (epmc).pdf DeepDyve Pubget Overpricing