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10.1155/2016/2636701 http://scihub22266oqcxt.onion/10.1155/2016/2636701 C4766347!4766347!26980944     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=26980944|t=2016. Metabolism Is Central to Tolerogenic Dendritic Cell Function |pdf=|usr=}}{{26980944}} gab.com Text Metabolism Is Central to Tolerogenic Dendritic Cell Function JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26980944 #FOAvip Immunological tolerance is a fundamental tenant of immune homeostasis and overall health. Self-tolerance is a critical component of the immune system that allows for the recognition of self, resulting in hyporeactivity instead of immunogenicity. Dendritic cells are central to the establishment of dominant immune tolerance through the secretion of immunosuppressive cytokines and regulatory polarization of T cells. Cellular metabolism holds the key to determining DC immunogenic or tolerogenic cell fate. Recent studies have demonstrated that dendritic cell maturation leads to a shift toward a glycolytic metabolic state and preferred use of glucose as a carbon source. In contrast, tolerogenic dendritic cells favor oxidative phosphorylation and fatty acid oxidation. This dichotomous metabolic reprogramming of dendritic cells drives differential cellular function and plays a role in pathologies, such as autoimmune disease. Pharmacological alterations in metabolism have promising therapeutic potential. Twit Text FOAVip Metabolism Is Central to Tolerogenic Dendritic Cell Function ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26980944 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26980944 #FOAvip English Wikipedia <ref>{{Cite pmid|26980944}}</ref> Metabolism Is Central to Tolerogenic Dendritic Cell Function #MMPMID26980944 Sim WJ; Ahl PJ; Connolly JE Mediators Inflamm 2016[]; 2016 (ä): ä PMID26980944show ga Immunological tolerance is a fundamental tenant of immune homeostasis and overall health. Self-tolerance is a critical component of the immune system that allows for the recognition of self, resulting in hyporeactivity instead of immunogenicity. Dendritic cells are central to the establishment of dominant immune tolerance through the secretion of immunosuppressive cytokines and regulatory polarization of T cells. Cellular metabolism holds the key to determining DC immunogenic or tolerogenic cell fate. Recent studies have demonstrated that dendritic cell maturation leads to a shift toward a glycolytic metabolic state and preferred use of glucose as a carbon source. In contrast, tolerogenic dendritic cells favor oxidative phosphorylation and fatty acid oxidation. This dichotomous metabolic reprogramming of dendritic cells drives differential cellular function and plays a role in pathologies, such as autoimmune disease. Pharmacological alterations in metabolism have promising therapeutic potential. äMetabolism Is Central to Tolerogenic Dendritic Cell Function (epmc).pdf DeepDyve Pubget Overpricing