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10.3389/fphys.2016.00061 http://scihub22266oqcxt.onion/10.3389/fphys.2016.00061 C4766307!4766307!26941655     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26941655|t=2016. Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis |pdf=|usr=}}{{26941655}} gab.com Text Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26941655 #FOAvip Renal fibrosis represents a common pathway leading to progression of chronic kidney disease. Renal interstitial fibrosis is characterized by extensive fibroblast activation and excessive production and deposition of extracellular matrix (ECM), which leads to progressive loss of kidney function. There is no effective therapy available clinically to halt or even reverse renal fibrosis. Although activated fibroblasts/myofibroblasts are responsible for the excessive production and deposition of ECM, their origin remains controversial. Recent evidence suggests that bone marrow-derived fibroblast precursors contribute significantly to the pathogenesis of renal fibrosis. Understanding the molecular signaling mechanisms underlying the recruitment and activation of the bone marrow-derived fibroblast precursors will lead to novel therapy for the treatment of chronic kidney disease. In this review, we summarize recent advances in our understanding of the recruitment and activation of bone marrow-derived fibroblast precursors in the kidney and the development of renal fibrosis and highlights new insights that may lead to novel therapies to prevent or reverse the development of renal fibrosis. Twit Text FOAVip Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26941655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26941655 #FOAvip English Wikipedia <ref>{{Cite pmid|26941655}}</ref> Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis #MMPMID26941655 Yan J; Zhang Z; Jia L; Wang Y Front Physiol 2016[]; 7 (ä): ä PMID26941655show ga Renal fibrosis represents a common pathway leading to progression of chronic kidney disease. Renal interstitial fibrosis is characterized by extensive fibroblast activation and excessive production and deposition of extracellular matrix (ECM), which leads to progressive loss of kidney function. There is no effective therapy available clinically to halt or even reverse renal fibrosis. Although activated fibroblasts/myofibroblasts are responsible for the excessive production and deposition of ECM, their origin remains controversial. Recent evidence suggests that bone marrow-derived fibroblast precursors contribute significantly to the pathogenesis of renal fibrosis. Understanding the molecular signaling mechanisms underlying the recruitment and activation of the bone marrow-derived fibroblast precursors will lead to novel therapy for the treatment of chronic kidney disease. In this review, we summarize recent advances in our understanding of the recruitment and activation of bone marrow-derived fibroblast precursors in the kidney and the development of renal fibrosis and highlights new insights that may lead to novel therapies to prevent or reverse the development of renal fibrosis. äRole of Bone Marrow-Derived Fibroblasts in Renal Fibrosis (epmc).pdf DeepDyve Pubget Overpricing