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10.4330/wjc.v8.i2.211 http://scihub22266oqcxt.onion/10.4330/wjc.v8.i2.211 C4766271!4766271!26981216     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Cardiol 2016 ; 8 (2): 211-9 Nephropedia Template TP {{tp|p=26981216|t=2016. Novel epigenetic-based therapies useful in cardiovascular medicine |pdf=|usr=}}{{26981216}} gab.com Text Novel epigenetic-based therapies useful in cardiovascular medicine JO: World J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26981216 #FOAvip Epigenetic modifications include DNA methylation, histone modifications, and microRNA. Gene alterations have been found to be associated with cardiovascular diseases, and epigenetic mechanisms are continuously being studied to find new useful strategies for the clinical management of afflicted patients. Numerous cardiovascular disorders are characterized by the abnormal methylation of CpG islands and so specific drugs that could inhibit DNA methyltransferase directly or by reducing its gene expression (e.g., hydralazine and procainamide) are currently under investigation. The anti-proliferative and anti-inflammatory properties of histone deacetylase inhibitors and their cardio-protective effects have been confirmed in preclinical studies. Furthermore, the regulation of the expression of microRNA targets through pharmacological tools is still under development. Indeed, large controlled trials are required to establish whether current possible candidate antisense microRNAs could offer better therapeutic benefits in clinical practice. Here, we updated therapeutic properties, side effects, and feasibility of emerging epigenetic-based strategies in cardiovascular diseases by highlighting specific problematic issues that still affect the development of large scale novel therapeutic protocols. Twit Text FOAVip Novel epigenetic-based therapies useful in cardiovascular medicine ????World J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=26981216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26981216 #FOAvip English Wikipedia <ref>{{Cite pmid|26981216}}</ref> Novel epigenetic-based therapies useful in cardiovascular medicine #MMPMID26981216 Napoli C; Grimaldi V; De Pascale MR; Sommese L; Infante T; Soricelli A World J Cardiol 2016[Feb]; 8 (2): 211-9 PMID26981216show ga Epigenetic modifications include DNA methylation, histone modifications, and microRNA. Gene alterations have been found to be associated with cardiovascular diseases, and epigenetic mechanisms are continuously being studied to find new useful strategies for the clinical management of afflicted patients. Numerous cardiovascular disorders are characterized by the abnormal methylation of CpG islands and so specific drugs that could inhibit DNA methyltransferase directly or by reducing its gene expression (e.g., hydralazine and procainamide) are currently under investigation. The anti-proliferative and anti-inflammatory properties of histone deacetylase inhibitors and their cardio-protective effects have been confirmed in preclinical studies. Furthermore, the regulation of the expression of microRNA targets through pharmacological tools is still under development. Indeed, large controlled trials are required to establish whether current possible candidate antisense microRNAs could offer better therapeutic benefits in clinical practice. Here, we updated therapeutic properties, side effects, and feasibility of emerging epigenetic-based strategies in cardiovascular diseases by highlighting specific problematic issues that still affect the development of large scale novel therapeutic protocols. äNovel epigenetic-based therapies useful in cardiovascular medicine (epmc).pdf DeepDyve Pubget Overpricing