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10.4254/wjh.v8.i6.340

http://scihub22266oqcxt.onion/10.4254/wjh.v8.i6.340
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C4766262!4766262!26962400
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suck abstract from ncbi


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pmid26962400      World+J+Hepatol 2016 ; 8 (6): 340-4
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  • Primary hepatic amyloidosis: A case report and review of literature #MMPMID26962400
  • Sonthalia N; Jain S; Pawar S; Zanwar V; Surude R; Rathi PM
  • World J Hepatol 2016[Feb]; 8 (6): 340-4 PMID26962400show ga
  • We describe a case of 42-year-old female presenting with abdominal pain associated with loss of weight and fever for 8 mo. On evaluation she had gross hepatomegaly with raised alkaline phosphatase and raised GGT levels with normal transaminases and bilirubin. On imaging she had diffuse enlargement of liver with heterogeneous contrast uptake in liver. Her viral marker and autoimmune markers were negative. Liver biopsy depicted massive deposition of amyloid in peri-sinusoidal spaces which revealed apple green birefringence on polarizing microscopy after Congo red staining. Cardiac and renal evaluation was unremarkable. Abdominal fat pad and rectum biopsy was negative for amyloid deposit. There was no evidence of primary amyloidosis as bone marrow examination was normal. Serum and urine immunofixation electrophoresis were normal. Immunoperoxidase staining for serum amyloid associated protein for secondary amyloidosis was negative from liver biopsy. We present this rare case of primary hepatic amyloidosis and review the literature regarding varied presentations of hepatic involvement in amyloidosis.
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