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http://scihub22266oqcxt.onion/ C4765695!4765695 !26958284     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26958284 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26958284 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       AMIA+Annu+Symp+Proc 2015 ; 2015 (ä): 1851-60 Nephropedia Template TP {{tp|p=26958284 |t=2015. Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson s disease |pdf=|usr=}}{{26958284 }} gab.com Text Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson s disease JO: AMIA Annu Symp Proc http://www.kidney.de/pget.php?&tw=1&pmid=26958284 #FOAvip Parkinson's disease (PD) is a severe neurodegenerative disorder without effective treatments. Here, we present a novel drug repositioning approach to predict new drugs for PD leveraging both disease genetics and large amounts of mouse model phenotypes. First, we identified PD-specific mouse phenotypes using well-studied human disease genes. Then we searched all FDA-approved drugs for candidates that share similar mouse phenotype profiles with PD. We demonstrated the validity of our approach using drugs that have been approved for PD: 10 approved PD drugs were ranked within top 10% among 1197 candidates. In predicting novel PD drugs, our approach achieved a mean average precision of 0.24, which is significantly higher (p<e-11) than 0.16 for a state-of-art drug discovery approach based on mouse phenotype data. Comparison of gene expression profiles between PD and top-ranked drug candidates indicates that quetiapine has the potential to treat PD. Twit Text FOAVip Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson s disease ????AMIA Annu Symp Proc http://www.kidney.de/pget.php?&tw=1&pmid=26958284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26958284 #FOAvip English Wikipedia <ref>{{Cite pmid|26958284 }}</ref> Combining Human Disease Genetics and Mouse Model Phenotypes towards Drug Repositioning for Parkinson s disease #MMPMID26958284 Chen Y ; Cai X ; Xu R AMIA Annu Symp Proc 2015[]; 2015 (ä): 1851-60 PMID26958284 show ga Parkinson's disease (PD) is a severe neurodegenerative disorder without effective treatments. Here, we present a novel drug repositioning approach to predict new drugs for PD leveraging both disease genetics and large amounts of mouse model phenotypes. First, we identified PD-specific mouse phenotypes using well-studied human disease genes. Then we searched all FDA-approved drugs for candidates that share similar mouse phenotype profiles with PD. We demonstrated the validity of our approach using drugs that have been approved for PD: 10 approved PD drugs were ranked within top 10% among 1197 candidates. In predicting novel PD drugs, our approach achieved a mean average precision of 0.24, which is significantly higher (p |*Drug Repositioning [MESH] |*Gene Expression Profiling [MESH] |Animals [MESH] |Drug Discovery [MESH] |Humans [MESH] |Mice [MESH] |Parkinson Disease/*drug therapy/*genetics [MESH]Combining Human Disease Genetics and Mouse Model Phenotypes towards Dr(epmc).pdf DeepDyve Pubget Overpricing