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10.1038/srep22113 http://scihub22266oqcxt.onion/10.1038/srep22113 C4764983!4764983 !26905812     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26905812 &cmd=llinks): Failed to open stream: HTTP request failed! 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The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma |pdf=|usr=}}{{26905812 }} gab.com Text The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26905812 #FOAvip Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might affect Wnt signaling remain to be elucidated. Here, we show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary SS. SS18-SSX is shown to interact with TCF/LEF, TLE and HDAC but not ?-catenin in vivo and to induce Wnt target gene expression by forming a complex containing promoter-bound TCF/LEF and HDAC but lacking ?-catenin. Our observations provide a tumor-specific mechanistic basis for Wnt target gene induction in SS that can occur in the absence of Wnt ligand stimulation. Twit Text FOAVip The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26905812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26905812 #FOAvip English Wikipedia <ref>{{Cite pmid|26905812 }}</ref> The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma #MMPMID26905812 Cironi L ; Petricevic T ; Fernandes Vieira V ; Provero P ; Fusco C ; Cornaz S ; Fregni G ; Letovanec I ; Aguet M ; Stamenkovic I Sci Rep 2016[Feb]; 6 (ä): 22113 PMID26905812 show ga Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might affect Wnt signaling remain to be elucidated. Here, we show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary SS. SS18-SSX is shown to interact with TCF/LEF, TLE and HDAC but not ?-catenin in vivo and to induce Wnt target gene expression by forming a complex containing promoter-bound TCF/LEF and HDAC but lacking ?-catenin. Our observations provide a tumor-specific mechanistic basis for Wnt target gene induction in SS that can occur in the absence of Wnt ligand stimulation. |Animals [MESH] |Axin Protein/genetics/metabolism [MESH] |Blotting, Western [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |Co-Repressor Proteins [MESH] |Gene Expression Profiling/*methods [MESH] |Histone Deacetylases/genetics/metabolism [MESH] |Humans [MESH] |Mice [MESH] |Microscopy, Confocal [MESH] |Oncogene Proteins, Fusion/*genetics/metabolism [MESH] |RNA Interference [MESH] |Repressor Proteins/genetics/metabolism [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Sarcoma, Synovial/genetics/metabolism/pathology [MESH] |TCF Transcription Factors/genetics/metabolism [MESH] |Transcription Factors/*genetics/metabolism [MESH] |Wnt Signaling Pathway/*genetics [MESH]The fusion protein SS18-SSX1 employs core Wnt pathway transcription fa(epmc).pdf DeepDyve Pubget Overpricing