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10.1042/BJ20151085

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C4764976!4764976!26635356
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suck abstract from ncbi


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pmid26635356      Biochem+J 2016 ; 473 (Pt 5): 605-14
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  • Circulating FGF21 proteolytic processing mediated by fibroblast activation protein #MMPMID26635356
  • Zhen E; Jin Z; Ackermann B; Thomas M; Gutierrez J
  • Biochem J 2016[Mar]; 473 (Pt 5): 605-14 PMID26635356show ga
  • Proteolytic cleavage of FGF21, evaluated in human plasma, confirmed three known proline hydrolysis sites. Although DPP-IV participates in consecutive cleavages from the N-terminus, fibroblast activation protein was implicated as the enzyme responsible for the C-terminal cleavage that inactivates FGF21.
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