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10.1038/srep21643 http://scihub22266oqcxt.onion/10.1038/srep21643 C4764852!4764852!26905650     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26905650|t=2016. The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and ?-catenin protein expression |pdf=|usr=}}{{26905650}} gab.com Text The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and -catenin protein expression JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26905650 #FOAvip Proper regulation of endothelial cell-cell contacts is essential for physiological functioning of the endothelium. Interendothelial junctions are actively involved in the control of vascular leakage, leukocyte diapedesis, and the initiation and progression of angiogenesis. We found that the RNA-binding protein quaking is highly expressed by endothelial cells, and that its expression was augmented by prolonged culture under laminar flow and the transcription factor KLF2 binding to the promoter. Moreover, we demonstrated that quaking directly binds to the mRNA of VE-cadherin and ?-catenin and can induce mRNA translation mediated by the 3?UTR of these genes. Reduced quaking levels attenuated VE-cadherin and ?-catenin expression and endothelial barrier function in vitro and resulted in increased bradykinin-induced vascular leakage in vivo. Taken together, we report that quaking is essential in maintaining endothelial barrier function. Our results provide novel insight into the importance of post-transcriptional regulation in controlling vascular integrity. Twit Text FOAVip The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and -catenin protein expression ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26905650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26905650 #FOAvip English Wikipedia <ref>{{Cite pmid|26905650}}</ref> The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and ?-catenin protein expression #MMPMID26905650 de Bruin RG; van der Veer EP; Prins J; Lee DH; Dane MJC; Zhang H; Roeten MK; Bijkerk R; de Boer HC; Rabelink TJ; van Zonneveld AJ; van Gils JM Sci Rep 2016[]; 6 (ä): ä PMID26905650show ga Proper regulation of endothelial cell-cell contacts is essential for physiological functioning of the endothelium. Interendothelial junctions are actively involved in the control of vascular leakage, leukocyte diapedesis, and the initiation and progression of angiogenesis. We found that the RNA-binding protein quaking is highly expressed by endothelial cells, and that its expression was augmented by prolonged culture under laminar flow and the transcription factor KLF2 binding to the promoter. Moreover, we demonstrated that quaking directly binds to the mRNA of VE-cadherin and ?-catenin and can induce mRNA translation mediated by the 3?UTR of these genes. Reduced quaking levels attenuated VE-cadherin and ?-catenin expression and endothelial barrier function in vitro and resulted in increased bradykinin-induced vascular leakage in vivo. Taken together, we report that quaking is essential in maintaining endothelial barrier function. Our results provide novel insight into the importance of post-transcriptional regulation in controlling vascular integrity. äThe RNA-binding protein quaking maintains endothelial barrier function(epmc).pdf DeepDyve Pubget Overpricing