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10.1186/s40348-016-0039-5

http://scihub22266oqcxt.onion/10.1186/s40348-016-0039-5
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C4764602!4764602!26905568
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suck abstract from ncbi


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pmid26905568      Mol+Cell+Pediatr 2016 ; 3 (ä): ä
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  • Update on host-pathogen interactions in cystic fibrosis lung disease #MMPMID26905568
  • Hector A; Frey N; Hartl D
  • Mol Cell Pediatr 2016[Dec]; 3 (ä): ä PMID26905568show ga
  • Bacterial and fungal infections are hallmarks of cystic fibrosis (CF) lung disease. In the era of long-term inhaled antibiotics and increasing CF patient survival, new ?emerging? pathogens are detected in CF airways, yet their pathophysiological disease relevance remains largely controversial and incompletely defined. As a response to chronic microbial triggers, innate immune cells, particularly neutrophils, are continuously recruited into CF airways where they combat pathogens but also cause tissue injury through release of oxidants and proteases. The coordinated interplay between host immune cell activation and pathogens is essential for the outcome of CF lung disease. Here, we provide a concise overview and update on host-pathogen interactions in CF lung disease.
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