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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Diagn+Microbiol+Infect+Dis
2016 ; 84
(3
): 268-73
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Diagnostic performance of a multiplex PCR assay for meningitis in an HIV-infected
population in Uganda
#MMPMID26711635
Rhein J
; Bahr NC
; Hemmert AC
; Cloud JL
; Bellamkonda S
; Oswald C
; Lo E
; Nabeta H
; Kiggundu R
; Akampurira A
; Musubire A
; Williams DA
; Meya DB
; Boulware DR
Diagn Microbiol Infect Dis
2016[Mar]; 84
(3
): 268-73
PMID26711635
show ga
Meningitis remains a worldwide problem, and rapid diagnosis is essential to
optimize survival. We evaluated the utility of a multiplex PCR test in
differentiating possible etiologies of meningitis. Cerebrospinal fluid (CSF) from
69 HIV-infected Ugandan adults with meningitis was collected at diagnosis (n=51)
and among persons with cryptococcal meningitis during therapeutic lumbar
punctures (n=68). Cryopreserved CSF specimens were analyzed with BioFire
FilmArray® Meningitis/Encephalitis panel, which targets 17 pathogens. The panel
detected Cryptococcus in the CSF of patients diagnosed with a first episode of
cryptococcal meningitis by fungal culture with 100% sensitivity and specificity
and differentiated between fungal relapse and paradoxical immune reconstitution
inflammatory syndrome in recurrent episodes. A negative FilmArray result was
predictive of CSF sterility on follow-up lumbar punctures for cryptococcal
meningitis. EBV was frequently detected in this immunosuppressed population
(n=45). Other pathogens detected included: cytomegalovirus (n=2), varicella
zoster virus (n=2), human herpes virus 6 (n=1), and Streptococcus pneumoniae
(n=1). The FilmArray Meningitis/Encephalitis panel offers a promising platform
for rapid meningitis diagnosis.