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in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Cancer
2016 ; 122
(5
): 773-81
Chronic medical conditions in adult survivors of retinoblastoma: Results of the
Retinoblastoma Survivor Study
#MMPMID26755259
Friedman DN
; Chou JF
; Oeffinger KC
; Kleinerman RA
; Ford JS
; Sklar CA
; Li Y
; McCabe MS
; Robison LL
; Marr BP
; Abramson DH
; Dunkel IJ
Cancer
2016[Mar]; 122
(5
): 773-81
PMID26755259
show ga
BACKGROUND: Limited data are available regarding long-term morbidity in adult
survivors of retinoblastoma (Rb). METHODS: The Retinoblastoma Survivor Study is a
retrospective cohort of adult survivors of Rb diagnosed between 1932 and 1994.
Participants completed a comprehensive questionnaire adapted from the Childhood
Cancer Survivor Study surveys. Chronic conditions were classified using the
National Cancer Institute's Common Terminology Criteria for Adverse Events
(version 4.03). Multivariate Poisson regression was used to compare survivors of
Rb with 2377 non-Rb controls, consisting of the Childhood Cancer Survivor Study
sibling cohort and survivors with bilateral versus unilateral disease. RESULTS:
Survivors of Rb (53.6% with bilateral disease) and non-Rb controls had a mean age
of 43.3 years (standard deviation, 11 years) and 37.6 years (SD, 8.6 years),
respectively, at the time of study enrollment. At a median follow-up of 42 years
(range, 15-75 years), 86.6% of survivors of Rb had at least 1 condition and 71.1%
had a severe/life-threatening (grade 3-4) condition. The adjusted relative risk
(RR) of a chronic condition in survivors compared with non-Rb controls was 1.4
(95% confidence interval [95% CI], 1.3-1.4; P<.01); for a grade 3 to 4 condition,
the RR was 7.6 (95% CI, 6.4-8.9; P<.01). Survivors were at an excess risk
regardless of laterality. After stratifying by laterality and excluding ocular
conditions and second malignant neoplasms (SMNs), only those with bilateral
disease were found to be at an increased risk of any nonocular, non-SMN condition
(RR, 1.2; 95% CI, 1.1-1.2) and for grade 3 to 4 nonocular, non-SMN conditions
(RR, 1.7; 95% CI, 1.2-2.5). CONCLUSIONS: Survivors of Rb have an increased risk
of chronic conditions compared with non-Rb controls. After excluding ocular
conditions and SMNs, this excess risk was found to persist only for those with
bilateral disease. Cancer 2016;122:773-781. © 2016 American Cancer Society.
Please enable JavaScript to view the comments powered by Disqus. |Adult
[MESH] |Case-Control Studies
[MESH] |Cataract/*epidemiology
[MESH] |Chronic Disease
[MESH] |Cohort Studies
[MESH] |Comorbidity
[MESH] |Diabetes Mellitus/epidemiology
[MESH] |Female
[MESH] |Follow-Up Studies
[MESH] |Hearing Loss/*epidemiology
[MESH] |Humans
[MESH] |Male
[MESH] |Middle Aged
[MESH] |Multivariate Analysis
[MESH] |Neoplasms, Second Primary/*epidemiology
[MESH] |Regression Analysis
[MESH] |Retinal Neoplasms/*epidemiology/therapy
[MESH] |Retinoblastoma/*epidemiology/therapy
[MESH] |Retrospective Studies
[MESH] |Stroke/epidemiology
[MESH] |Survivors/*statistics & numerical data
[MESH] |Thyroid Nodule/*epidemiology
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