Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/hep.28389 http://scihub22266oqcxt.onion/10.1002/hep.28389 C4764418!4764418!26662852     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26662852&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hepatology 2016 ; 63 (3): 799-812 Nephropedia Template TP {{tp|p=26662852|t=2016. NKp46+ NK cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation |pdf=|usr=}}{{26662852}} gab.com Text NKp46+ NK cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=26662852 #FOAvip Non-alcoholic steatohepatitis (NASH) affects 3?5% of the U. S. population having severe clinical complications to the development of fibrosis and end-stage liver diseases such as cirrhosis and hepatocellular carcinoma. A critical cause of NASH is chronic systemic inflammation promoted by innate immune cells such as liver macrophages (M?) and natural killer (NK) cells. However, little is known about how the crosstalk between M? and NK cells contributes to regulate NASH progression to fibrosis. In this report, we demonstrate that NKp46+ cells play an important role in preventing NASH progression to fibrosis by regulating M1/M2 polarization of liver M?. Using a murine model of NASH, we demonstrate that DX5+NKp46+ NK cells are increased during disease and play a role in polarizing M? toward M1-like phenotypes. This NK?s immunoregulatory function depends on the production of IFN-? but not by granzyme-mediated cytolytic activity. Notably, depletion of NKp46+ cells promote the development of fibrosis with increased expression of profibrogenic genes as well as skewed M2 M? phenotypes in hepatic tissues.Conclusion: NK cell-derived IFN-? may be essential for maintaining a balanced inflammatory environment that promotes tissue integrity and limiting NASH progression to fibrosis. Twit Text FOAVip NKp46+ NK cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=26662852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26662852 #FOAvip English Wikipedia <ref>{{Cite pmid|26662852}}</ref> NKp46+ NK cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation #MMPMID26662852 Tosello-Trampont AC; Krueger P; Narayanan S; Landes SG; Leitinger N; Hahn YS Hepatology 2016[Mar]; 63 (3): 799-812 PMID26662852show ga Non-alcoholic steatohepatitis (NASH) affects 3?5% of the U. S. population having severe clinical complications to the development of fibrosis and end-stage liver diseases such as cirrhosis and hepatocellular carcinoma. A critical cause of NASH is chronic systemic inflammation promoted by innate immune cells such as liver macrophages (M?) and natural killer (NK) cells. However, little is known about how the crosstalk between M? and NK cells contributes to regulate NASH progression to fibrosis. In this report, we demonstrate that NKp46+ cells play an important role in preventing NASH progression to fibrosis by regulating M1/M2 polarization of liver M?. Using a murine model of NASH, we demonstrate that DX5+NKp46+ NK cells are increased during disease and play a role in polarizing M? toward M1-like phenotypes. This NK?s immunoregulatory function depends on the production of IFN-? but not by granzyme-mediated cytolytic activity. Notably, depletion of NKp46+ cells promote the development of fibrosis with increased expression of profibrogenic genes as well as skewed M2 M? phenotypes in hepatic tissues.Conclusion: NK cell-derived IFN-? may be essential for maintaining a balanced inflammatory environment that promotes tissue integrity and limiting NASH progression to fibrosis. äNKp46+ NK cells attenuate metabolism-induced hepatic fibrosis by regul(epmc).pdf DeepDyve Pubget Overpricing