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10.1002/hep.28389 http://scihub22266oqcxt.onion/10.1002/hep.28389 C4764418!4764418 !26662852     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26662852 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hepatology 2016 ; 63 (3 ): 799-812 Nephropedia Template TP {{tp|p=26662852 |t=2016. NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice |pdf=|usr=}}{{26662852 }} gab.com Text NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice JO: Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=26662852 #FOAvip Nonalcoholic steatohepatitis (NASH) affects 3%-5% of the U.S. population, having severe clinical complications to the development of fibrosis and end-stage liver diseases, such as cirrhosis and hepatocellular carcinoma. A critical cause of NASH is chronic systemic inflammation promoted by innate immune cells, such as liver macrophages (M?) and natural killer (NK) cells. However, little is known about how the crosstalk between M? and NK cells contributes to regulate NASH progression to fibrosis. In this report, we demonstrate that NKp46(+) cells play an important role in preventing NASH progression to fibrosis by regulating M1/M2 polarization of liver M?. Using a murine model of NASH, we demonstrate that DX5(+)NKp46(+) NK cells are increased during disease and play a role in polarizing M? toward M1-like phenotypes. This NK's immunoregulatory function depends on the production of interferon-gamma (IFN-?), but not by granzyme-mediated cytolytic activity. Notably, depletion of NKp46(+) cells promotes the development of fibrosis with increased expression of profibrogenic genes as well as skewed M2 M? phenotypes in hepatic tissues. CONCLUSIONS: NK cell-derived IFN-? may be essential for maintaining a balanced inflammatory environment that promotes tissue integrity and limiting NASH progression to fibrosis. Twit Text FOAVip NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice ????Hepatology http://www.kidney.de/pget.php?&tw=1&pmid=26662852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26662852 #FOAvip English Wikipedia <ref>{{Cite pmid|26662852 }}</ref> NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice #MMPMID26662852 Tosello-Trampont AC ; Krueger P ; Narayanan S ; Landes SG ; Leitinger N ; Hahn YS Hepatology 2016[Mar]; 63 (3 ): 799-812 PMID26662852 show ga Nonalcoholic steatohepatitis (NASH) affects 3%-5% of the U.S. population, having severe clinical complications to the development of fibrosis and end-stage liver diseases, such as cirrhosis and hepatocellular carcinoma. A critical cause of NASH is chronic systemic inflammation promoted by innate immune cells, such as liver macrophages (M?) and natural killer (NK) cells. However, little is known about how the crosstalk between M? and NK cells contributes to regulate NASH progression to fibrosis. In this report, we demonstrate that NKp46(+) cells play an important role in preventing NASH progression to fibrosis by regulating M1/M2 polarization of liver M?. Using a murine model of NASH, we demonstrate that DX5(+)NKp46(+) NK cells are increased during disease and play a role in polarizing M? toward M1-like phenotypes. This NK's immunoregulatory function depends on the production of interferon-gamma (IFN-?), but not by granzyme-mediated cytolytic activity. Notably, depletion of NKp46(+) cells promotes the development of fibrosis with increased expression of profibrogenic genes as well as skewed M2 M? phenotypes in hepatic tissues. CONCLUSIONS: NK cell-derived IFN-? may be essential for maintaining a balanced inflammatory environment that promotes tissue integrity and limiting NASH progression to fibrosis. |Animals [MESH] |Cell Death [MESH] |Collagen/metabolism [MESH] |Disease Progression [MESH] |Female [MESH] |Fibrosis [MESH] |Hepatic Stellate Cells/metabolism [MESH] |Immunity, Innate [MESH] |Interferon-gamma/metabolism [MESH] |Killer Cells, Natural/*physiology [MESH] |Liver/*immunology/pathology [MESH] |Macrophage Activation [MESH] |Macrophages/*physiology [MESH] |Mice, Inbred C57BL [MESH] |Natural Cytotoxicity Triggering Receptor 1/metabolism [MESH] |Non-alcoholic Fatty Liver Disease/*immunology/pathology [MESH] |Phenotype [MESH] |Receptor Cross-Talk [MESH] |T-Lymphocytes, Regulatory [MESH]NKp46(+) natural killer cells attenuate metabolism-induced hepatic fib(epmc).pdf DeepDyve Pubget Overpricing