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10.1016/j.semnephrol.2015.04.006

http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2015.04.006
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C4764351!4764351!26215864
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suck abstract from ncbi


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pmid26215864      Semin+Nephrol 2015 ; 35 (3): 266-78
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  • Morphology in the Digital Age: Integrating High Resolution Description of Structural Alterations with Phenotypes and Genotypes #MMPMID26215864
  • Nast CC; Lemley KV; Hodgin JB; Bagnasco S; Avila-Casado C; Hewitt SM; Barisoni L
  • Semin Nephrol 2015[May]; 35 (3): 266-78 PMID26215864show ga
  • Conventional light microscopy (CLM) has been used to characterize and classify renal diseases, evaluate histopathology in studies and trials, and educate renal pathologists and nephrologists. The advent of digital pathology, in which a glass slide can be scanned to create whole slide images (WSI) for viewing and manipulating on a computer monitor, provides real and potential advantages over CLM. Software tools such as annotation, morphometry and image analysis can be applied to WSIs for studies or educational purposes, and the digital images are globally available to clinicians, pathologists and investigators. New ways of assessing renal pathology with observational data collection may allow better morphologic correlations and integration with molecular and genetic signatures, refinements of classification schema, and understanding of disease pathogenesis. In multicenter studies, WSI, which require additional quality assurance steps, provide efficiencies by reducing slide shipping and consensus conference costs, and allowing anytime anywhere slide viewing. While validation studies for the routine diagnostic use of digital pathology still are needed, this is a powerful tool currently available for translational research, clinical trials and education in renal pathology.
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